The increase in glucose level may be due to stress caused by rumen impaction which leads to release of adrenocorticosteroid release, which has glycogenolytic
effect causing hyperglycemia (Hussain and Uppal, 2012).
An excessive catecholamine activity, through a glycogenolytic
effect, contributes to a rise in blood glucose levels.
G6PC, a critical enzyme for providing glucose during starvation and diabetes , is involved in the terminal step in gluconeogenic and glycogenolytic
pathways and catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate.
It has previously been demonstrated that an elevated [H.sup.+] from a first high intensity interval may completely inhibit glycogen phosphorylase activity (glycogenolytic
flux) and simultaneously maintain a high level of pyruvate dehydrogenase activity during subsequent high intensity intervals which means a shift towards a greater reliance on oxidative phosphorylation (Parolin et al., 1999).
General objective: The implementation of an EU registry of patients with McArdle disease and very rare muscle glycogenolytic
disorders (MGD) with exercise intolerance as the major symptom (PR-MDMGD).
Furthermore, the defect in glycogenolytic
pathways and limited lipolysis also contribute to the occurrence of hypoglycaemia in undernutrition.