The translational activities of specific metabolic signals, such as glycolytic
flux, in cardiac myocytes are altered in the maladaptation of the heart (Taegtmeyer etal., 2005).
For example, scallops use anaerobic glycolytic
metabolism when exposed to environmental hypoxia, and when they experience functional hypoxia after intense swimming or escaping from predators, which is supported by adductor muscle contractions (Chih & Ellington 1983).
"Unlike the regular form of Max, Delta Max actually enhances c-MYC activity, specifically by promoting the glycolytic
phenotype of the tumor cells," said Mischel.
Chronic depletion of mitochondrial DNA in both Schwann cells and Dorsal root ganglion neurons in vitro has resulted in decreased enzyme activities of various Krebs cycle enzymes including Malate dehydrogenase, Citrate Synthase and a simultaneous increase in Glycolytic
Under anaerobic conditions, LDH becomes an important enzyme due to its ability to regenerate [NAD.sup.+] and allows for continued carbon flow through the glycolytic
pathway to support anaerobic ATP synthesis .
We found that the expression of many key glycolytic
enzymes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and L-lactate dehydrogenase B chain (LDHB), fructose-bisphosphate aldolase A and C (ALDOA, ALDOC), phosphoglycerate kinase 1 (PGK1), alpha-enolase (ENO1), pyruvate kinase isozymes M1/M2 (PKM2), and L-lactate dehydrogenase A chain (LDHA), was drastically reduced in SKBR3_shVPS4B cells.
Recent reports indicate that mTOR activation is a key regulator of the Warburg effect leading to upregulation of glycolytic
This is also called the Glycolytic
Pathway and the metabolism of glucose is referred to as glycolysis.
The archaeal glycolytic
hexokinase activity were increased.
The researchers chose this specific system, called glycolytic
oscillations, to perform a virtual test of the software because it is one of the most extensively studied biological control systems.
However, if the cell needs to produce nucleotides, the oxidative pathway of the PPP will be inhibited and glycolytic
intermediates will be used to generate R5P in the non-oxidative phase of the PPP.
In fact, many experts refer to MODY as being either "glucokinase diabetes" (resulting from mutations in the gene that encodes the glycolytic
enzyme glucokinase) or "transcription factor diabetes" (resulting from mutations in genes that encode various transcription factors).