Results in the first patient dosed with ABO-101 suggest strong CNS and broader systemic distribution, with the potential to reduce levels of glycosaminoglycans
(GAGs) that represent the lysosomal storage pathology central to MPS IIIB disease progression.
Relationsh between cartilage glycosaminoglycan
content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.
There is an effective injectable polysulfated glycosaminoglycan
, Adequan, available through your veterinarian.
Targeting human cancer by a glycosaminoglycan
binding malaria protein.
(GAG) content in the cartilage, quantified as [micro]g per mg dry weight.
Smoking has been shown to increase the synthesis of hyaluronic acid by orbital fibroblasts in adipose tissue; furthermore, tissue hypoxia induced by smoking results in the generation of free radicals, which in turn induce the proliferation of orbital fibroblasts and stimulate glycosaminoglycan
synthesis and adipogenesis.
(GAGs) and proteoglycans (PG) in addition to collagen are the main components of extracellular matrix (ECM).
Chondroitin sulfate is a sulfated glycosaminoglycan
which is, as mentioned above, of vital importance for cartilage health.
Although crucial in clinical thrombotic events, unfractionated heparin (UHEP), a 1,4-linked linear glycosaminoglycan
variously sulfated consisting of [beta]-D-glucosamine (N-sulfated or acetylated) and uronic acid ([beta]-D-glucuronic acid or [alpha]-L-iduronic acid) residues, and extracted from animal tissues, manifests extensive bleeding side effects (mainly hemorrhage) (Nader et al.
It's a long-term condition with no known cure, and while the exact cause isn't clear, one theory is that it may be linked to a defect or failure in the bladder's protective glycosaminoglycan
(GAG) layer, which increases bladder wall permeability and allows toxic substances through, leading to chronic inflammation.
The exact cause isn't clear, but one theory is that it may be linked to a defect or failure in the bladder's protective glycosaminoglycan
layer (GAG), which increases bladder wall permeability and allows toxic substances through, leading to chronic inflammation.
3, 6) Experimental treatments that have been reported include topical glycosaminoglycan
and radiation therapy.