MPS is characterized by the accumulation of glycosaminoglycans
("GAGs"), polysaccharides which are important for the modulation of cellCaetoCaecell signaling and the maintenance of tissue structure and function, in the lysosomes of cells.
Neurogenic locus notch homolog protein (NOTCH), nitric oxide synthetase (NOS), soluble guanylate cyclase (sGC), Cyclic guanosine monophosphate (cGMP), tryptophan hydroxylase 1 (TPH 1), serotonin type 2B receptor (5HT2BR), phospholipase C (PLC), extracellular-signal regulated kinase (ERK), transforming growth factor (3 (TGFP), Receptor I (RI), Receptor II (RII), mother against decantaplegic homolog (Smad), smooth muscle actin ([alpha]SMA), non-muscle embryonic myosin (Smemb), glycosaminoglycan
(GAG), proteoglycan (PG), matrix metalloproteinases (MMPs).
(GAG) layer maintains the integrity of the urothelium, tight junctions and urothelial permeability (28-30).
Accordingly, in our other project, which is currently underway, our aim is to examine target genes such as ChSy-1 and C4ST-1, enzymes responsible for the synthesis and elongation of the glycosaminoglycan
chain of biglycan proteoglycan.
Using this new system, ISCO scientists generated a healthy cartilage-specific matrix from human mesenchymal stem cells that had significantly higher viability and cartilage specific properties, including: proteoglycan, aggrecan, hyaluronic acid, and collagen II deposition and glycosaminoglycan
Mucopolysaccharidosis (MPS) is composed of a group of rare inherited lysosomal storage disorders of the mucopolyssacharide, or glycosaminoglycan
 Possible causative factors are defect in glycosaminoglycan
(GAG) layer, dysregulated immune or inflammatory signals, neural hypersensitivity and pelvic floor dysfunction.
Meanwhile, chondroitin sulfate is a glycosaminoglycan
comprised of N-acetyl-galactosamine and glucuronic acid.
Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan
(GAG) content in cartilage.
Hyaluranon is a glycosaminoglycan
(essentialy a protein) widely found in connective, epithelial and neural tissues.
Ologen is composed of a porous matrix of cross-linked atelocollagen and glycosaminoglycan
. It contains thousands of microscopic pores and can induce fibroblast growth, leading to a minimal scarring and low immunogenicity healing process.
Electrospun fiber assembled hydrogel was also utilized for supplementation of glycosaminoglycan
enriched and mineralized cartilage .