goserelin


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go·se·rel·in

 (gō′sə-rĕl′ĭn)
n.
A synthetic peptide analog of gonadotropin-releasing hormone used to treat prostate cancer, endometriosis, and advanced breast cancer.

[Blend of gonadorelin (from gonado(tropin-)rel(easing hormone) + -in) and serine.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Translations

goserelin

n goserelina
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
However, Gonadotrophin releasing hormone agonist called goserelin has shown satisfactory results in pelvic congestion syndrome treatment pain.
In MONALEESA-7, Kisqali plus an aromatase inhibitor and goserelin nearly doubled the median PFS compared to an aromatase inhibitor and goserelin alone in pre- or perimenopausal women.
Gonadotropin-releasing hormone (GnRH) analogues, including both GnRH agonists (nafarelin, leuprolide, and goserelin) and GnRH antagonists (elagolix) reduce pelvic pain caused by endometriosis by suppressing pituitary secretion of LH and FSH, thereby reducing ovarian synthesis of estradiol.
In a large randomised multicentre study for the treatment of mastalgia, goserelin (LHRH analog) has shown effect as short-term treatment.
LHRH analogs include; leuprolide (Lupron, Eligard), goserelin (Zoladex), triptorelin (Trelstar), and histrelin (Vantas).
Ovarian ablation versus goserelin with or without tamoxifen in pre-perimenopausal patients with advanced breast cancer: results of a multicentric Italian study.
For such patients, ovarian function must be ablated either with surgery or with gonadotropin-releasing hormone (GnRH) analogues such as leuprorelin and goserelin if aromatase inhibitors are desired.
Prevention of Menopause Induced by Chemotherapy (PROMISE) (21) isimli randomize kontrollu calismada kemoterapi sirasinda Triptorelin ve Goserelin kullaniminin ovaryan yetmezlik gelisimini anlamli sekilde azalttigi gozlenmistir (21).
She said gonadotropin-releasing hormone agonises, such as Zoladex (Goserelin) will cause the estrogen and progesterone levels to drop.
Single-centre Bicalutamide 50 mg daily 153 during the first 4 weeks L, LA, & met Kawakami LHRH(a) (goserelin, leuprolide, 2013 (11) or buserelin) Single-centre 69 Met Dason 2013 (10) LHRH(a) (goserelin, leuprolide, Cohort series or triptorelin), 3-month depots 32 and a 1-month course of L, LA, & met bicalutamide on ADT initiation OR LHRH antagonist (degarelix), 1-month depots Study type/n/ T level setting Klotz [less than or equal to]0.7 nmol/l 2015 (8) RCT, (NT year 1; Multicentre n=489) 626 >0.7 to <1.7 Recurrent nmol/l (NT year 1; n=129) [greater than or equal to]1.7 nmol/l (NT year 1; n=8) Wang 2016 (12) [less than or equal to]0.9 nmol/l Single-centre (n=98) 206 Met >0.9 nmol/l (n=108) Bertaglia <0.7 nmol/l 2013 (9) (n=25)vs.
Cyclic therapy (Gn-RH agonist, leuprolide acetate 1.88 mg, or goserelin acetate 1.8 mg via subcutaneous injection six times every 4 weeks for 24 weeks; DNG, 2 mg/day, oral administration 24-108 weeks) was continued alternately for approximately eight years as endometriosis treatment.