Enlivex has completed a phase IIa clinical trial to prevent
graft-versus-host disease in a matched donor population.
In univariable models, the researchers found that prior chronic lymphocytic leukemia (CLL) (hazard ratio, 2.2), chronic
graft-versus-host disease (GVHD) (HR, 3.1), and age at transplant of more than 60 years (HR, 10.8) were all linked to an increased risk for squamous cell carcinomas.
The US Food and Drug Administration (FDA) has extended the review period for United States-based Incyte's supplemental new drug application (NDA) for acute
graft-versus-host disease (GVHD) treatment, Jakafi (ruxolitinib), it was reported on Friday.
Graft-versus-host disease (GVHD) of the gastrointestinal (GI) tract is a common complication of hematopoietic stem cell transplant (HSCT) and is associated with significant morbidity and mortality.
'Bone marrow transplants from partially matched donors carry about an 80 percent risk of
graft-versus-host disease and the myxoma treatment would address that,' Cogle added.
MELBOURNE, Australia, May 24, 2018 -- Australian stem cell and regenerative medicine company Cynata Therapeutics Limited (ASX:CYP) announced that the final patient was treated in Cohort B of its Phase 1 clinical trial of CYP-001, its Cymerus mesenchymal stem cell (MSC) product candidate, in steroid-resistant acute
graft-versus-host disease (GvHD).
MELBOURNE, Australia, May 24, 2018 --Australian stem cell and regenerative medicine company Cynata Therapeutics Limited (ASX:CYP) announced that the final patient was treated in Cohort B of its Phase 1 clinical trial of CYP-001, its Cymerus mesenchymal stem cell (MSC) product candidate, in steroid-resistant acute
graft-versus-host disease (GvHD).
Bscheider et al., "Activity of therapeutic JAK 1/2 blockade in
graft-versus-host disease," Blood, vol.
Graft-versus-host disease (GVHD), an immune-mediated disease caused by complex interactions between donor and recipient immune systems, is a leading cause of morbidity and mortality following HSCT [4, 6, 7].
Fisher et al., "A retrospective analysis of therapy for acute
graft-versus-host disease: initial treatment," Blood, vol.
Graft-versus-host disease is a complication of bone marrow transplants that can cause problems including skin rash, shortness of breath, abdominal pain, jaundice and muscle weakness.
