granulocyte-macrophage colony-stimulating factor


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Related to granulocyte-macrophage colony-stimulating factor: GM-CSF

granulocyte-macrophage colony-stimulating factor

n. Abbr. GM-CSF
1. A cytokine secreted by a variety of cell types that stimulates progenitor cells in the bone marrow to produce granulocytes (especially neutrophils) and macrophages.
2. A recombinant form of this cytokine, such as the drug sargramostim.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
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Granulocyte-macrophage colony-stimulating factor (GM-CSF)
VBI-1901 is administered intradermally and is adjuvanted with granulocyte-macrophage colony-stimulating factor (GM-CSF), a potent adjuvant that mobilizes dendritic cell function.
(NASDAQ: SVRA) has received disappointing top line data from IMPALA, a pivotal Phase 3 clinical study evaluating Molgradex, an inhaled formulation of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), for the treatment of aPAP, the company said.
We evaluated the concentrations of a select panel of cytokines, including innate immune mediators (interferon [IFN]-[gamma], interleukin [IL]-15, IFN-P); inflammatory factors (IL-6, IL-18, soluble intercellular adhesion molecule 1 [sICAM-1]); chemokines (CC-motif chemokine ligand [CCL] 3, CCL-4, CXC-motif chemokine ligand [CXCL] 1, CXCL-8, CXCL-10); hematopoietic factors (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor); the angiogenic factor vascular endothelial growth factor A (VEGF-A); and proteases (matrix metalloproteinase [MMP]-2, MMP-9).
Granulocyte-macrophage colony-stimulating factor is a critical pro-inflammatory cytokine that plays a pivotal role in tissue inflammation and destruction in autoimmune and inflammatory diseases.
TJM2 is a humanised immunoglobulin G1 (IgG1) targeting granulocyte-macrophage colony-stimulating factor (GM-CSF) and is the first candidate from I-Mab's innovative proprietary pipeline to be approved for clinical trials by the FDA.
To achieve this purpose, the impact of FR in mice receiving HFD or HCD during 56 days on serum levels of basic fibroblast growth factor (FGF-basic), granulocyte-macrophage colony-stimulating factor (GM-CSF), inducible protein 10 (IP-10), interferon [gamma] (IFN-[gamma]), interleukin 1[alpha] (IL-1[alpha]), IL-1[beta], IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, keratinocyte chemoattractant (KC), macrophage inflammatory protein-1[alpha] (MIP-1-[alpha]), monocyte chemotactic protein 1 (MCP-1), monokine induced by IFN-[gamma] (MIG), and tumor necrosis factor [alpha] (TNF-[alpha]) were evaluated.
Instead, they saw much more granulocyte-macrophage colony-stimulating factor (GM-CSF) than they expected.
Granulocyte-macrophage colony-stimulating factor prevents the progression of atherosclerosis via changes in the cellular and extracellular composition of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits.
These immune cells also secrete IL-33, granulocyte-macrophage colony-stimulating factor (GMCSF), IL-10, and chemokine ligand 27 (CCL27) and are capable of expressing Toll-like receptors (TLRs) and NACHT, LRR, and PYD domain-containing protein 3 (NLRP3), which is a component of the inflammatory process mediated by IL1.
Abbreviations ISHAGE - International Society for Hematotherapy and Graft Engineering SC - stem cell MSC - mesenchymal stem cell GM-CSF - granulocyte-macrophage colony-stimulating factor M-CSF - granulocyte colony-stimulating factor DMSO - dimethyl sulfoxide HES - hydroxyetil starch ACD - acid-citrate-dextrose TNC - total nucleated cell MNC - mononuclear cell LVL - large volume leukapheresis GvHD - graft versus host disease MRA - marrow repopulating ability CFU-S - colony-forming unit spleen CFU-GM - colony-forming unit granulocyte-macrophage Generally, SCs can be divided into embryonic and adult cell compartment, but several adult SCs have a similar high-level ("unlimited") biological potential to embryonic cells [2, 4].

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