Research progress on the effect of traditional Chinese medicine intervention on the secretion function of ovarian granulose
cells and the expression of related factors.
The cells surrounding the oviposition site go through metaplasic reaction, and the cytoplasm becomes granulose
. Gall development proceeds by cell hypertrophy and hyperplasia of surrounding tissues.
After the treatment period, granulose
cells were harvested and rinsed with PBS.
In humans hyperprolactinemia is associated with a marked reduction in both the frequency and amplitude of LH pulses,14 indirectly suggesting that both the brain and pituitary might be targets for prolactin.1 The increase observed in prolactin may be the cause of low estrogen and progesterone concentration in the infertile females.1 In vitro increase in prolactin level inhibits progesterone secretion in human porcine granulose
cells.15 A study demonstrated that high levels of prolactin, inhibit follicular steroidogenesis not only by interfering with aromatase activity but also by reducing the production by the theca of the androgen precursors necessary for oestrogen production.1
As a result of chemotherapy, the natural aging process of the ovaries accelerates, because steroid-secreting cells (granulose
and theca cells) and some of the primordial follicles are damaged and follicular failure develops (10).
A study of human granulose
tumour cell lines suggests that IL-6 may impair oestradiol synthesis by the granulosa cells of the ovary.
 Basically, the ovarian follicle consists of two components: An outer thecal layer and an inner granulose
The malignancies/borderline tumors included three leiomyosarcomas, two endometrial sarcomas, two endometrioid adenocarcinomas, one granulose
cell tumor, three smooth muscle tumors of uncertain malignant potential, three atypical leiomyoma, and one serous papillary borderline ovarian tumor.
Published data indicate that the direct effect of melatonin on follicular steroid production is complex and may depend on the cell type (theca cell or granulose
cell), duration of treatment (acute or long-term response), experimental model (cell culture or follicle culture), species, and dose .
Another possible explanation for this is that follicular granulose
cells that sprinkle estrogen were dispersed.
Superoxide dismutase activity has been shown in the granulose
and theca cells of the follicle, where glutathione peroxidase enzyme is localized in follicular fluid (2).
Molecular basis of bone Morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulose