United States-based Perrigo and its partner Allergan have introduced guaifenesin
1200mg extended-release tablets to retail and wholesale customers, it was reported yesterday.
* Consider use of guaifenesin
and/or NAC to improve cervical and male fluid quality.
In addition to amoxicillin or placebo, all patients also used as-needed acetaminophen, guaifenesin
, dextromethorphan, pseudoephedrine, and nasal saline spray.
She had tried multiple over-the-counter cough suppressants, including dextromethorphan and guaifenesin
, as well as cough drops, but none had been effective.
Each package of Kids-EEZE Chest relief contains 12 individually wrapped soft chews with 100 mg of guaifenesin
. It carries a suggested retail price of $7.99.
Apart from bronchodilators, actively heated ("old fashioned") humidification of the air stream (to 376), vibro-percussion, appropriate body positioning and encouragement to cough, reasonable interventions include therapeutic bronchoscopy, aerosolized acetylcysteine (Mucomyst), guaifenesin
(Mucinex) and an old tried and true remedy-aerosolized bicarbonate.
Many dextromethorphan-laced preparations contain other active compounds--such as pseudoephedrine, acetaminophen, chlorpheniramine, guaifenesin
, or bromide--that can cause serious adverse effects at above-normal doses.
The only timed-release products containing guaifenesin
that have been formally approved by the FDA are those marketed over the counter as Mucinex or Humibid, by Adams Respiratory Therapeutics.
In a substudy, patients were tested on their understanding of the instruction, "Take two tablets by mouth twice daily," on a bottle of guaifenesin
. Overall, 84% were able to correctly state the instruction, but fewer patients knew how many pills to take.
These medications usually consist of a combination of antipyretic analgesics (e.g., acetaminophen or ibuprofen), antitussives (e.g., dihydrocodeine phosphate or noscapine), expectorants (e.g., bromohexine hydrochloride, guaifenesin
, or potassium guaiacolsulfonate), exogenous enzyme (e.g., lysozyme chloride), bronchodilator (e.g., dl-methylephedrine hydrochloride), antihistaminics (e.g., carbinoxamine maleate or mequitazine), vitamins (e.g., vitamin B1, B2, or vitamin C), and others (e.g., herbal medicines or caffeine).
For example, due to regulatory approval in July 2002, Mucinex expectorant became the only FDA-approved single-ingredient, extended-release guaifenesin
tablet available on the market and was awarded market exclusivity on Dec.
A recent study compared the effectiveness of two combination products -- guaifenesin
with either codeine or dextromethorphan--to to a placebo.