(2001) had speculated that a Phe-excess diet could modulate the inhibition of food intake by guanethidine
, which induces a chronic lack of noradrenaline at postsynaptic adrenoceptors.
Effects of regional intravenous guanethidine
block in posttraumatic cold intolerance in hand amputees.
(48) Intravenous regional anesthesia with guanethidine
is no longer recommended, and recent studies emphasize the risk of significant adverse effects.
Ganglionic blockade with guanethidine
followed by cholinergic stimulation with neostigmine can be effective.
Acute iv blockade of the release of norepinephrine from peripheral sympathetic nerves with guanethidine
or iv pretreatment with propranolol (a non-selective [beta]-adrenergic antagonist) abolished the effect of dipyrone on GE, suggesting the involvement of the sympathetic nervous system (SNS), and activation of [[beta].sub.1]- and/or [[beta].sub.2]-adrenergic receptors during the phenomenon (24).
In addition, paeoniflorin could reverse hypotensive Wistar rats induced by guanethidine
, revealing a two-way method of regulating the effects of BP .
Intravenous regional sympathetic block with guanethidine
. Lancet 1974;1:1019-20.
These included oral and spinal opioids, antidepressants, multiple intravenous regional blocks with guanethidine
, ankle blocks, and acupuncture.
Cardiac scintigraphy using [sup.123]I-metaidodobenzylguanidine ([sup.123]I-MIBG), a radioisotope form of guanethidine
, has also been used to detect Lewy body disease.
(2) intravenous regional anaesthesia with guanethidine
depletes peripheral catecholamine and can relieve sympathetically maintained pain, intradermal injection of norepinephrine rekindles sympathetically maintained pain in patients who have previously undergone sympathectomy and topical application of clonidine has been shown to eliminate hyperalgesia only at the site of drug application.
fDE FA High wDE High fDE Low fDE Low fDE wDE and TRP Low wDE Vehicle TRPA1 antagonist (5 mg/kg, IP) TRP antagonist (2.5 mg/kg, IP) TRPV1 antagonist (5 mg/kg, IP) FA TRPA1 antagonist (5 mg/kg, IP) TRP antagonist (2.5 mg/kg, IP) TRPV1 antagonist (5 mg/kg, IP) wDE and autonomics LowwDE Vehicle Vagotomy Atropine (0.5 mg/kg, IP) Guanethidine
(5 mg/kg, IP) FA Vagotomy Atropine (0.5 mg/kg, IP) Guanethidine
(5 mg/kg, IP) IP, intraperitoneal; TRPA1 antagonist, HC030031; TRP antagonist, RR;TRPV1 antagonist, SB366791.
Effect of regional sympathetic blockade with guanethidine
. Acta Neurol Scand 1988;77:187-91.