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Polychromasia is also seen in extramedullary haemopoiesis due to myeloid metaplasia in reticulo-endothelial tissue.
stimulates secretion of the circulating cytokines IL-6 and G-CSF by the vascular endothelium suggests an alternative, indirect mechanism by which IL-3 could influence haemopoiesis in the bone marrow.
Cytopaenias are due, in part, to the stimulated immune system releasing proinflammatory cytokines, which suppress haemopoiesis in the bone marrow.