Also found in: Medical, Encyclopedia, Wikipedia.
Related to hapten: complete antigen, Tolerogen


 (hăp′tĕn′) also hap·tene (-tēn′)
A small molecule that reacts with a specific antibody but does not induce an immune response unless bound to a larger molecule, usually a protein.

[German : Greek haptein, to fasten + German -en, noun suffix (from Greek -ēnē, -ene).]

hap·ten′ic adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˈhæptən) or


(Physiology) immunol an incomplete antigen that can stimulate antibody production only when it is chemically combined with a particular protein
[C20: from German, from Greek haptein to fasten]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈhæp tɛn)

also hap•tene


a substance that reacts with antibodies but cannot by itself stimulate more antibodies; a partial antigen.
[1920–25; < German < Greek hápt(ein) to grasp + German -en -ene]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
The etiopathogenesis of the responsible drug has not been fully elucidated although it is believed to be associated with basal keratinocytes acting as a hapten and causing antibody-dependent cellular cytotoxicity.
The determination of affinity of monoclonal antibody and hapten with Lu-CL reaction enhancement has been reported [131].
During the next contact with the same hapten, in the dermis, the antigen-presenting cells (APCs) present the neoantigen to the memory CD8+ lymphocytes, which develop the effector cytotoxic T lymphocyte (CTL) function.
2-keto-3-deoxy-D-glycero-D-galac to-nononic acid is a relatively low-molecular-weight molecule of hapten character (4).
These findings showed that the priming of naive T cells to PPD failed, suggesting that an essential individual susceptibility factor may have been missing from the in vitro T cell priming assay or that PPD did not react to form a hapten.
It is hypothesized that hydralazine is metabolized by myeloperoxidase released from activated neutrophils to form reactive intermediate metabolites, which can act as hapten for MPO and result in formation of anti-MPO antibody (14).
In some susceptible individuals, metabolites may not be perfectly detoxified and instead act as a hapten and initiate an immunologic response that results in cellular necrosis [1, 5].
The potential scope of [sup.68]Ga-based imaging agents is rather extensive including ligands specifically targeting receptors, enzymes, and antigens; hapten and effector molecules involved in pretargeted imaging; small molecules with biological function to monitor glycolysis, hypoxia, cell proliferation, and angiogenesis; nontargeting particles of various sizes for imaging of ventilation and perfusion [4].
The upstream internal primer UplnSJNdv (5'-GATTTCGTTCCATTCTcTtG-3') was indicative for the SJNNV genotype and labelled with the hapten digoxigenin (Dig) at the 5' end.
Furthermore, azathioprine has an inactive metabolite, methyl nitroimidazole, which may be responsible for the hypersensitivity reactions due to the generation of a hapten during metabolism [4, 9, 11, 12].