The targets are said to be enzymes within the helicase
and histone acetyltransferase (HAT) families, which when dysregulated were linked to the development of cancers that currently does not have therapeutic options.
Boehringer Ingelheim and Epizyme will jointly research and develop a helicase
program, with both parties sharing U.S.
Repair of G-Quadruplex DNA Facilitated by the FANCJ Helicase
and the REV1 Polymerase.
The chromodomain helicase
DNA-binding proteins (CHDs) are a family of nine members named CHD 1-9, which act as regulators of chromatin remodeling process and gene expression in humans.
Furthermore, Regnase-1 associates with UPF1, an RNA helicase
essential for the mRNA quality control system called nonsense mediated RNA decay (NMD).
Herr founded Helicase
, an Arlington, Virginia-based company that develops products to enhance mental and physical performance.
The first study to apply next-generation sequencing to amniocentesis samples (16) used low-coverage sequence data to detect a balanced translocation disrupting the gene chromodomain helicase
DNA binding protein 7 (CHD7)  and most likely resulting in a severe congenital syndrome.
Two fetal genomes had potentially detrimental variants in chromodomain helicase
DNA binding protein 8 and low-density lipoprotein receptor-related protein 1; variations of these have been linked to autism spectrum disorder and keratosis pilaris atrophicans, respectively.
Among 3 ASD candidate genes for the family number 2, CHD8 encodes chromodomain helicase
DNA binding protein 8 which functions as a transcription repressor by transforming chromatin structure.
RTS type II has been recognized as a genetically transmitted disorder of the RECQL4 gene, affecting the RECQL4 DNA helicase
and thus leading to genomic instability .
The protein comprises two caspase-activation and recruitment domains (2CARDs) at the N-terminal region, an RNA helicase
domain, and a C-terminal domain (CTD) (Figure 1(a)).
Two predicted domains (the helicase
and the polymerase ones) were identified in AltMV RdRp amino acid sequence by the BLAST algorithm .