Among such residues, an amino acid at position 212 of hemagglutinin-esterase-fusion protein determined hemagglutinin
antigenicity of the virus; lysine or arginine at this position resulted in heterologous antigenicities (9).
Flu viruses have two major antigens, hemagglutinin
and neuraminidase, which determine the specific strain of flu virus.
They engineered the virus to produce the version of a protein, called hemagglutinin
, that is found on either the bird-flu virus known as H5N1 or the one called H7N7.
The isolated virus was identified as a highly pathogenic H5N1, with hemagglutinin
proteolytic cleavage site deduced amino acid sequence of QREKRKKR/GLFGAIAG.
The two organizations will develop at least one vaccine for each of 16 variations of hemagglutinin
, a key influenza surface protein.
(HA) of avian influenza virus strains shows preferential binding to SA[alpha]2,3 receptors, which partially accounts for the reduced ability of avian influenza strains to establish infections in humans (3).
To address this question, Sasisekharan and his team analyzed the structure of the H5N1 and H7N9 viruses, focusing on hemagglutinin
(HA)-a type of viral protein that binds to cell receptors in the respiratory tract of hosts.
Fluzone High-Dose is formulated so that each 0.5 mL dose contains a total of 180 micrograms (mcg) of influenza virus hemagglutinin
(HA) which is made up of 60 mcg of each of the three influenza virus strains.
By mixing and matching the 1918 virus' genes with genes from contemporary-flu strains, the team found that the 1918 virus' polymerase genes and its hemagglutinin
gene, which sneaks the virus into cells, seem to play pivotal roles in virulence.
gene of this virus was distantly related to those of H5N1 subtypes that have caused infections in humans since 1997 (3).
Ferritin was fused genetically with hemagglutinin
(HA), the protein found on the surface of the influenza virus, resulting in a nanoparticle with eight protruding viral spikes.