The basement membrane of the RPE joins the Bruch membrane in the hemidesmosome
regions, which contains laminin filaments, collagen types IV and V, and proteoglycans .
The relevant data showed that 47-64% of patients with diabetes might suffer from primary keratopathy, and its clinical features mainly include decreased corneal sensitivity, delayed epithelium healing, neurotrophic corneal ulcer, and other symptoms and it even causes blindness.,, Primary keratopathy in patients with diabetes is mainly associated with the change in the components of corneal epithelial basement membrane, decrease in the junction number of hemidesmosome
, accumulation of advanced glycated end products, change in growth factors, corneal nerve-ending injury, oxidative stress, and other abnormalities under diabetic conditions.,
The pathogenesis of BP is characterized by tissue-bound and circulating IgG autoantibodies against two components of the hemidesmosome
, BP230 and BP180 .
Mainly IgG autoantibodies bind to BP 230 and BP 180 antigens, components of the hemidesmosome
adhesion complex, triggering activation of complement and release of tissue-destructive enzymes.1
Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix reorganization but independent of basement membrane and hemidesmosome
Analysis of the interactions between BP180, BP230, plectin and the integrin [alpha]6[beta]4 important for hemidesmosome
formation, which was observed along the collagen fibres and extensions, was demonstrated.
(5) Pemphigoid disorders are immune processes, involving an immunoglobulin G (IgG) immune response directed at a 180-kDa hemidesmosome
eIF6 is originally identified in mammals as a cytoplasmic interactor of [sz]4 integrin, which is crucial in hemidesmosome
formation, cell adhesion, and responsible for the blister formation of hypertrophic scar surface.
Immunolocalization of this protein to the hemidesmosome
. J Clin Invest.
A laminin-5-rich matrix is capable of inducing rapid cell adhesion as well as hemidesmosome
assembly in a squamous cell carcinoma line (SCC12) (Langhofer et al., 1993; Baker et al., 1996).
Pemphigoid diseases are a heterogeneous group of chronic autoimmune disorders that are characterized by autoantibodies directed against various structural proteins of the hemidesmosomes
, resulting in epithelial detachment (18).