hemochromatosis


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he·mo·chro·ma·to·sis

 (hē′mə-krō′mə-tō′sĭs)
n.
A condition, usually hereditary, in which excessive amounts of iron accumulate in body tissues, characterized by fatigue, joint pain, and bronze or gray pigmentation of the skin, and if untreated, leading to complications such as liver dysfunction and diabetes mellitus.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

he•mo•chro•ma•to•sis

(ˌhi məˌkroʊ məˈtoʊ sɪs)

n.
a disorder of iron metabolism manifested by bronzed skin due to excessive iron absorption, leading to joint pain, diabetes, and liver damage if iron concentration is not reduced.
[1895–1900; hemo- + Greek chrōmat-, s. of chrôma color + -osis]
he`mo•chro`ma•tot′ic (-ˈtɒt ɪk) adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hemochromatosis - pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints
pathology - any deviation from a healthy or normal condition
classic hemochromatosis, idiopathic hemochromatosis - inherited form of hemochromatosis
acquired hemochromatosis - hemochromatosis resulting from repeated transfusions or from excessive intake of foods containing iron
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

he·mo·chro·ma·to·sis

[MIM*235200]
n. hemocromatosis, trastorno del metabolismo férrico acompañado por exceso de depósitos de hierro en los tejidos que causa anomalías de pigmentación de la piel, cirrosis hepática y diabetes.
English-Spanish Medical Dictionary © Farlex 2012

hemochromatosis

n hemocromatosis f
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Hereditary hemochromatosis is an auto-somal recessive disorder which is characterized by increased intestinal absorption of dietary iron more than twice that of normal3, due to excessive retention of iron in the circulatory system it may lead to various pathological changes in body including fatigue, arthralgia, abdominal pain, and loss of sex drive.
Undiagnosed hemochromatosis, for example, can lead to liver failure.
However, if their doctors had known of their hemochromatosis, the patients could have donated blood on a regular basis to get rid of the excess iron, thus avoiding a risky transplant.
Hereditary hemochromatosis (HH) is a rare disorder related to mutations in the HFE gene (1).
We limited our review to adult patients because hemochromatosis is extremely rare in childhood.
[3] showed that conditional deletion of HFE in the liver induces a hemochromatosis phenotype, while its conditional deletion in duodenal cells or macrophages does not have the same effect on iron metabolism.
The second finding reported in the study by Soltanpour et al, (12) was the association between the human hemochromatosis protein (HFE) gene related mutations and iron overload in patients with TDT.
The prevalence of diabetes decreased among hemochromatosis case series published in the interval 1935-1998 (Figure 1).
MRI of the abdomen demonstrated iron deposition in the liver and spleen compatible with secondary hemochromatosis. Liver biopsy documented increased iron uptake in the hepatocytes and Kupffer cells (Figure 1).
His past medical history was notable for hemochromatosis, migraines, restless leg syndrome, and obstructive sleep apnea.
GALD-NH, previously known as neonatal hemochromatosis, typically presents as subacute fetal liver injury and/or congenital cirrhosis [3].
Nonetheless, studies on both humans and animals clearly demonstrate that an excessive iron accumulation, resulting from a medical condition (e.g., hemochromatosis) or dietary intake can have a range of deleterious effects including cancer, heart diseases, lower fitness level, and many others [3-5].