heparan sulfate


Also found in: Medical, Acronyms, Wikipedia.
Related to heparan sulfate: keratan sulfate, dermatan sulfate

hep·a·ran sulfate

 (hĕp′ə-răn)
n.
A glycosaminoglycan found on cell surfaces and basement membranes in mammals that regulates a wide variety of biological processes, including angiogenesis and blood coagulation. Also called heparitin sulfate.

[hepar(in) (to which it is close in structure) + -an.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Mentioned in ?
References in periodicals archive ?
The study primary endpoints are neurodevelopment and safety, with secondary endpoints including behavior evaluations, quality of life, enzyme activity in cerebrospinal fluid (CSF) and plasma, heparan sulfate levels in CSF, plasma and urine, and brain and liver volume.
MPS II is a genetic lysosomal storage disease caused by deficiency of the iduronate-2-sulfatase enzyme which is needed to break down or recycle glycosaminoglycans dermatan sulfate and heparan sulfate. Without IDS enzyme, the GAGs accumulate in nearly all organs and body tissues.
The basement membrane proteoglycans, namely a large agrin-LP (CGI_10007223) and heparan sulfate proteoglycan (perlecan-LP, CGI_10025660), are expressed differently from other genes in oyster development.
Urinary GAG was elevated in all patients and increased dermatan sulfate and heparan sulfate was seen in GAG electrophoresis of 9 patients.
Wismans et al., "Removal of heparan sulfate from the glomerular basement membrane blocks protein passage," Journal of the American Society of Nephrology, vol.
Park et al., "Functions of cell surface heparan sulfate proteoglycans," Annual Review of Biochemistry, vol.
Caruelle, "Pharmacological studies of RGTA(11), a heparan sulfate mimetic polymer, efficient on muscle regeneration," Journal of Biomedical Materials Research, vol.
(3) Heparan sulfate. Heparan sulfate has been identified in small amounts in the vitreous, and its role is to maintain adequate spacing between the collagen fibrils.
Heparan sulfate is present on the surface and in the extracellular matrix of all mammalian cells and serves as an attachment factor or anchor for a number of enveloped viruses such as herpes simplex virus [20], respiratory syncytial virus [21], human immunodeficiency virus [22], cytomegalovirus [23], Dengue virus [24], HBV [25], and HCV [26], as well as non-enveloped viruses such as human papillomavirus [27] and foot-and-mouth disease virus [28].
Syndecan is rich in heparan sulfate and chondroitin sulfate chains.