heparan sulfate


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Related to heparan sulfate: keratan sulfate, dermatan sulfate

hep·a·ran sulfate

 (hĕp′ə-răn)
n.
A glycosaminoglycan found on cell surfaces and basement membranes in mammals that regulates a wide variety of biological processes, including angiogenesis and blood coagulation. Also called heparitin sulfate.
[hepar(in) (to which it is close in structure) + -an.]
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The large reductions in heparan sulfate in both CSF and urine, significant organ changes and demonstration of neurocognitive benefits represent important findings that support our path to regulatory guidance later this year.
United States : Abeona Therapeutics Reports Top-Line Data from Phase 1/2 Gene Therapy Trial in MPS IIIA
Heparan sulfate (HS) plays a primary role in cell-to-cell communications.
Preventing and treating skin aging, Part II
Sanfilippo B, a lysosomal storage disease, is caused by deficiency in the enzyme alpha-N-acetyglucosaminidase (NAGLU), one of the four enzymes required for heparan sulfate degradation.
BioMarin Reports on Study of BMN 250 for Treatment of Sanfilippo B Syndrome (MPS IIIB) at ICIEM 2017
HSA, she continued, "is an analog of endogenous heparan sulfate, a biologically active glycosaminoglycan (GAG) that has been described as the most information-dense biopolymer in nature due to the multiple functions that can perform such as rebalanced dermal matrix health, deep dermal hydration and modulating the activity of key secreted factors and enzymes.
What's in your formula? A look at the ingredients beauty brands are using to fuel their formulations and capture consumers' attention
The testing of urinary samples included an untargeted analysis of low-molecular-mass metabolites using selective reaction monitoring LC-MS/MS with conditions detailed in Tables 2 and 3 and a targeted analysis of selected proteins and heparan sulfate [15-19].
Toward noninvasive diagnosis of IgA nephropathy: a pilot urinary metabolomic and proteomic study
sup][3],[4] Human sulfatase 1 (Hsulf-1) is a recently characterized endosulfatase that selectively removes sulfate groups from heparan sulfate proteoglycans (HSPG), thereby altering the binding sites on HSPG for signaling molecules.
Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo
Heparan sulfate proteoglycans of the cardiovascular system.
The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease
Heparan sulfate plays a central role in a dynamic in vitro model of protein-losing enteropathy.
Protein losing enteropathy in children/Cocuklarda protein kaybettiren enteropati
One of them is genetic engineering of BMPs to increase binding capacity to the extracellular matrix components such as heparin and heparan sulfate proteoglycans (HSPGs) (8).
Periplasmic expression of a novel human bone morphogenetic protein-7 mutant in Escherichia coli
Changes in heparan sulfate correlate with increased glomerular permeability.
Diabetic Nephropathy: progression and pathophysiology
We also observed a non-metachromatic fraction migrating between dermatan sulfate and the heparan sulfate standard.
Purification and characterization of hyaluronic acid from chicken combs/Purificacao e caracterizacao do acido hialuronico obtido da crista de frango
The essential conditions found for the transglycosylation reaction are as follows: (38) (i) acceptors are peptides bearing a serine residue, and (ii) acceptable donors are any ChS (Ch, Ch4S and Ch6S), DS or heparan sulfate (HS) that possesses a linkage region, although the order of efficiency is ChS > DS > HS.
Synthesis of neoproteoglycans using the transglycosylation reaction as a reverse reaction of endo-glycosidases

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