The study primary endpoints are neurodevelopment and safety, with secondary endpoints including behavior evaluations, quality of life, enzyme activity in cerebrospinal fluid (CSF) and plasma, heparan sulfate
levels in CSF, plasma and urine, and brain and liver volume.
proteoglycans as adhesive and anti-invasive molecules.
The effect of heparan sulfate
application on bone formation during distraction osteogenesis.
MPS II is a genetic lysosomal storage disease caused by deficiency of the iduronate-2-sulfatase enzyme which is needed to break down or recycle glycosaminoglycans dermatan sulfate and heparan sulfate
. Without IDS enzyme, the GAGs accumulate in nearly all organs and body tissues.
The basement membrane proteoglycans, namely a large agrin-LP (CGI_10007223) and heparan sulfate
proteoglycan (perlecan-LP, CGI_10025660), are expressed differently from other genes in oyster development.
Urinary GAG was elevated in all patients and increased dermatan sulfate and heparan sulfate
was seen in GAG electrophoresis of 9 patients.
Wismans et al., "Removal of heparan sulfate
from the glomerular basement membrane blocks protein passage," Journal of the American Society of Nephrology, vol.
Park et al., "Functions of cell surface heparan sulfate
proteoglycans," Annual Review of Biochemistry, vol.
Caruelle, "Pharmacological studies of RGTA(11), a heparan sulfate
mimetic polymer, efficient on muscle regeneration," Journal of Biomedical Materials Research, vol.
(3) Heparan sulfate
. Heparan sulfate
has been identified in small amounts in the vitreous, and its role is to maintain adequate spacing between the collagen fibrils.
is present on the surface and in the extracellular matrix of all mammalian cells and serves as an attachment factor or anchor for a number of enveloped viruses such as herpes simplex virus , respiratory syncytial virus , human immunodeficiency virus , cytomegalovirus , Dengue virus , HBV , and HCV , as well as non-enveloped viruses such as human papillomavirus  and foot-and-mouth disease virus .
Syndecan is rich in heparan sulfate
and chondroitin sulfate chains.