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 (hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)
1. The quality or condition of being toxic or destructive to the liver.
2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.


(Medicine) damaging to the liver
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.hepatotoxic - toxic to the liver
toxic - of or relating to or caused by a toxin or poison; "suffering from exposure to toxic substances"
References in periodicals archive ?
A few cases of viper bites developed predominantly hepatotoxic features with minimal local reaction and was not found to be responding adequately to anti-snake venom, but did not go on to develop any complications.
No known hepatotoxic medications had been taken in the previous month.
Oral pre-treatment with aqueous and ethanolic leaf extracts at a dose of 500 mg/kg body weight showed no hepatotoxic damage before [CCl.
Limitations of the study: The study was carried out in a single tertiary care hospital of Lahore, use of any prior or concomitant hepatotoxic drugs was not ruled out.
The amount of niacinamide used in this study is equivalent to 35 g per day for a 70-kg person, a dose that is hepatotoxic in humans.
Furthermore, we examined IVIVE potential for specific human hepatotoxic endpoints such as drug-induced liver injury, hepatocellular injury, and cholestatic injury.
Introduction: Unsaturated pyrrolizidine alkaloids have long been considered hepatotoxic and potentially carcinogenic, and herbs containing them are banned from use in Australia.
AIH is a unique clinical entity, which cannot be explained solely on the basis of chronic viral infection model, alcohol consumption, or exposure to hepatotoxic medications and chemicals contact.
The reason for acetaminophen's continued sales regardless of its hepatotoxicity is because acetaminophen is only hepatotoxic at high concentrations; when used at therapeutic levels it's an effective pain reliever.
As a result of the enzyme block, hepatotoxic intermediates such as maleyland fumarylacetoacetic acids accumulate and are ultimately metabolized to succinylacetone (SUAC), a highly specific marker for TYR1 (1) (Fig.
The biochemical analysis revealed significant increased ALT AST and bilirubin, which supported the histological findings that nickel sulphate, is hepatotoxic.
AST and ALT reduction suggests that the extract might not be hepatotoxic or nephrotoxic since there was no significant leakage of the enzymes from the liver or the kidney of the treatment group of the mice.