The addition of Jack's business acumen, as well as his understanding of partnering strategies and the intricacies of drug development and the regulatory approval process, enhances our ability to deliver a high-value preventative compound that addresses an unmet medical need and stands out amongst all the other currently-approved drugs that act only to shorten herpes labialis
(cold sores) outbreaks, rather than prevent them.'
Exclusion criteria also include patients who were on isotretinoin therapy, patients with infections such as herpes labialis
and critically ill patients.
Recurrent herpes labialis
during isotretinoin therapy: is there a role for photosensitivity?
Differential diagnosis for this type of cheilitis includes recurrent herpes labialis
(if lesions are unilateral) and secondary syphilis (fissured papules at the corners of the lips similar to cheilitis) (2,9).
Contraindications for microneedling include patients with an active infection (such as herpes labialis
), acne, and a predisposition for keloid scarring.
Also, the history of recurrent infection (herpes labialis
infection, streptococcal pharyngitis, and EBV pharyngitis) can only be explained by the patient's severe form of MBL deficiency (level is <0.5ng/ML) that led to immunosuppression and increased susceptibility to recurrent infection.
Available by prescription only (Denavir, 2016), penciclovir is indicated for treatment of recurrent herpes labialis
(cold sores) on the lips and face; application on mucous membranes is not recommended.
(15.) Downing C, Moayyad J, Tamirisa A, Tyring S, Acyclovir Lauriad[R]: A muco-adhesive buccal tablet for the treatment of recurrent herpes labialis
, Expert Rev Anti-Infect Ther 12(3), 283-287, 2014.
Other less commonly seen infections were herpes labialis
, warts, molluscum contagiosum, impetigo, DCPA (Dermatitis cruris pustulosa et atrophicans), folliculitis decalvans, pityriasis versicolor, sporotrichosis, and leprosy.
[USPRwire, Wed Apr 13 2016] GlobalData's clinical trial report, "Herpes Labialis
(Oral Herpes) Global Clinical Trials Review, H1, 2016" provides an overview of Herpes Labialis
(Oral Herpes) clinical trials scenario.
In this laboratory experimental study, HSV-1 virus was isolated from patient lip lesion with recurrent herpes labialis
and was confirmed by neutralization test using an anti-HSV-1 pig antiserum (NIH, USA) .