Lyme, Bartonella henselae, and heterophile
antibodies were also negative.
Lymphocytosis with numerous atypical lymphocytes and elevated liver enzymes are most often observed in conjunction with the detection of EBV-specific serologies or heterophile
Treatment with polyethylene glycol precipitates large-molecular-weight compounds such as IgG and can help identify heterophile
antibodies and antigen-bound antibodies.
The presence of heterophile
antibodies in the serum can interfere with the assay and produce false-positive tests.
EBV IgG and IgM were positive, but heterophile
assay and EBV PCR was negative (Table 1).
However, other factors not investigated in this work, such as age differences in sensitivity to RDT, rheumatoid factor cross-reacting in the blood , and cross-reactivity with heterophile
antibodies , can be responsible for false positive result in RDT.
Early or failing intrauterine pregnancies, ectopic pregnancies, heterophile
antibodies, and hCG-secreting tumors are examples of medical conditions that could initially present as PUL [2, 3].
antibody test was negative, however, as were EBV titers.
antibody test yielded a positive result the day after admission, and a clinical diagnosis of infectious mononucleosis was confirmed 7 days later with positive Epstein–Barr virus (EBV) serology-positive viral capsid antigen immunoglobulin M, negative viral capsid antigen immunoglobulin G (IgG), and EBV nuclear antigen IgG.
However, before making a decision on the need for definitive treatment, a diagnosis should be made to distinguish between transient thyroiditis in the recovery phase and non-thyroid disease with changes in the hormonal profile, (26) or even laboratory interference (heterophile
Okouchi, "Antigen of "serum sickness" type of heterophile
antibodies in human sera: identification as gangliosides with N glycolylneuraminic acid," Biochemical and Biophysical Research Communications, vol.
Her EBV viral capsid antigen (VCA) antibodies IgM and IgG were positive at 1.3 and >8.0, respectively; and her early antigen antibody, nuclear antigen antibody, and heterophile
antibody were all negative, indicating acute primary infection (BioPlex 2200 EBV IgM and IgG Kits).