heterophile antibody


Also found in: Thesaurus, Medical, Encyclopedia.
Related to heterophile antibody: heterophile antigen
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.heterophile antibody - an antibody found in the blood of someone suffering from infectious mononucleosis
antibody - any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
References in periodicals archive ?
A heterophile antibody test was negative, however, as were EBV titers.
The combination of a patient having greater than 50% lymphocytes and greater than 10% atypical lymphocytes is also useful.[sup][2] However, the Hoagland criteria state that in patients presenting with clinically suspected infectious mononucleosis, the diagnosis should be confirmed using the heterophile antibody (monospot) test.
Her EBV viral capsid antigen (VCA) antibodies IgM and IgG were positive at 1.3 and >8.0, respectively; and her early antigen antibody, nuclear antigen antibody, and heterophile antibody were all negative, indicating acute primary infection (BioPlex 2200 EBV IgM and IgG Kits).
The diagnosis is confirmed by serology; the presence of heterophile antibody is used as a rapid screening test with a sensitivity of 70-90% and specificity of 96-99% with rare false positives occurring in conditions such as viral hepatitis and Cytomegalovirus infection [9].
Testing for cTnT was repeated with the hs-cTnT assay after treatment with heterophile antibody blocking agents and remained increased.
Investigation of primary human immunodeficiency virus infection in patients who test positive for heterophile antibody. Clin Infect Dis.
Blood cultures, monospot test (a form of the heterophile antibody test for infectious mononucleosis due to Epstein-Barr virus), and serology for hepatitis viruses were all negative.
But it has the disadvantage that the test sera need to be absorbed free from heterophile antibody. (2)
The sharing of antigens between rickettsia and proteus is the basis of this heterophile antibody test.
(The presence of a heterophile antibody can interfere with immunoassay tests such as hCG.
The possibility of heterophile antibody interference was investigated with an HBT.
The diagnosis relies on atypical lymphocytes which resemble monocytes or on heterophile antibody tests which assess agglutination with sheep, guinea pig and horse red cells.