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Related to heterozygosity: Loss of heterozygosity


1. Having different alleles at one or more corresponding chromosomal loci.
2. Of or relating to a heterozygote.

het′er·o·zy·gos′i·ty (-ə-rō-zī-gŏs′ĭ-tē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biology) the condition of being a heterozygote
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.heterozygosity - the state of being heterozygous; having two different alleles of the same gene
state - the way something is with respect to its main attributes; "the current state of knowledge"; "his state of health"; "in a weak financial state"
homozygosity - the state of being homozygous; having two identical alleles of the same gene
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive ?
Microsatellite data analysis: Popgene 1.32 (Yeh and Boyle 1997) was used to estimate the number of alleles (NA) and effective number of alleles (NE), and CERVUS 3.0 (Kalinowski et al., 2007) was employed to calculate the polymorphic information content (PIC), expected heterozygosity (HE) and observed heterozygosity (HO).
These features include the analysis of human leukocyte antigen loss of heterozygosity, the presence (or absence) of seven of the most common oncogenic viruses, as well as the composition of the T-cell receptor alpha repertoire, which is complementary to the previously-released TCR beta analysis.
Statistical analysis for calculation of genetic variability measures such as number of alleles, expected and observed heterozygosity, homozygosity and Polymorphic Information Content (PIC) was calculated for all microsatellite markers.
The number of alleles (NA), observed (HO) heterozygosity and expected (HE) heterozygosity were calculated using ARLEQUIN ver.
The converted data was processed using POPGEN version 1:32 program [11] to generate the observed number of alleles ([n.sub.a]), effective number of alleles ([n.sub.e]), observed heterozygosity value ([H.sub.o]), expected heterozygosity value ([H.sub.e]), genetic differentiation ([F.sub.ST]), the global heterozygote deficit among breeds ([F.sub.IT]), and the heterozygote deficit within the breed ([F.sub.IS]), gene flow (Nm), Hardy-Weinberg equilibrium (HW), and allele frequency.
The number of allele, and expected and observed heterozygosity were characterized in the wild population of Panjin, China.
The three DNA abnormalities examined in the study, all of which are included in the PancraGEN(R) assay, included: elevated DNA quantity, KRAS mutation, and loss of heterozygosity mutations among a panel of key tumor suppressor genes.
Arlequin software version 3.5 was used to calculate allele frequencies and to obtain expected heterozygosity (He), observed heterozygosity (Ho) and probability value (p-value) of Hardy-Weinberg equilibrium (7).
In this present study, the cultured population showed a higher level of inherent genetic diversity and allele richness than the wild as revealed by indicators such as the percentage of polymorphic loci (%P), Number of Alleles (Na), Number of effective alleles (Ne), Shannon Information index (I), and expected heterozygosity (Nei's gene diversity).
According to Hardy-Weinberg, and to the fixation index (f), the intrapopulation genetic variability has been quantified through the number of alleles per locus (A), the percentage of polymorphic loci (P) and the observed (Ho) and expected (He) heterozygosity (Ho) (Hamrick, 1983).
Different measurements of within breed genetic variations like observed and expected heterozygosity, Shannon index and polymorphic parameters (the number of actual alleles and the number of effective alleles) were calculated using POPGENE software package (Yeh et al., 1999).