These EPSPs were blocked by hexamethonium
, leading to the proposal that CBI-11 signaling could be mediated by acetylcholine, in addition to GABA and FCAP (Wu et al., 2014; see Table 1).
The arterial BP and HR lowering effects of VO (i.v.) in anaesthetised rats were antagonised by cyproheptadine, hexamethonium
, atropine and pretreatment with reserpine (87).
The QUATS compounds that did not show mitochondrial inhibition are: clidinium bromide, hexamethonium
bromide, tolonium chloride, and cefalonium.
For the investigation of mechanisms involved in the extract hypotensive action, certain drugs were tested after 30 minutes of stabilization: N[beta]-nitro-L-arginine methyl ester (L-NAME), an nitric oxide (NO) synthesis inhibitor (30 mg/kg, n = 6); losartan, AT1 receptor antagonist of angiotensin II (10 mg/kg, n = 6); and hexamethonium
, a ganglionic blocker (20 mg/kg, n = 6) [21-23].
Therefore, the Fade caused by antinicotinic (hexamethonium
) agent may be severe (~ 89%) when the concentration of such agent is causing 25% [TOF.sub.fade] (Pereira, Sa, & Prado, 2012).
Although the decline after the 1950s can be partially explained by the development and use of drugs that effectively lowered blood pressure (i.e., hexamethonium
, hydralazine, rauwolfia, and methyldopa), the reason for the decline previous to 1950 was unknown as of 1975 (Rosen 1975).
The preparations were preincubated with either atropine or hexamethonium
and then exposed to [alpha]-hederin.
Similar to this finding, it has been showed that also the BP increase can be attenuated by pharmacological blockade of the autonomic nervous system with hexamethonium
, indicating that it is mediated by the SNS rather than by mechanical factors related to changes in intrathoracic pressure.
asthma study and the death of a normal volunteer in research.
An example occurred in summer 2001 when a volunteer on a Johns Hopkins research project died when she was given hexamethonium
One of the most visible examples happened in summer 2001 when a volunteer on a Johns Hopkins research project died when she was given hexamethonium
He enlisted healthy volunteers to inhale a chemical irritant, hexamethonium
. One of the volunteers, a technician at the Johns Hopkins Asthma and Allergy Center, died.