hexamethonium


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hexamethonium

(ˌhɛksəmɪˈθəʊnɪəm)
n
(Pharmacology) a ganglionic blocker used to relieve hypertension
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
These EPSPs were blocked by hexamethonium, leading to the proposal that CBI-11 signaling could be mediated by acetylcholine, in addition to GABA and FCAP (Wu et al., 2014; see Table 1).
The arterial BP and HR lowering effects of VO (i.v.) in anaesthetised rats were antagonised by cyproheptadine, hexamethonium, atropine and pretreatment with reserpine (87).
The QUATS compounds that did not show mitochondrial inhibition are: clidinium bromide, hexamethonium bromide, tolonium chloride, and cefalonium.
For the investigation of mechanisms involved in the extract hypotensive action, certain drugs were tested after 30 minutes of stabilization: N[beta]-nitro-L-arginine methyl ester (L-NAME), an nitric oxide (NO) synthesis inhibitor (30 mg/kg, n = 6); losartan, AT1 receptor antagonist of angiotensin II (10 mg/kg, n = 6); and hexamethonium, a ganglionic blocker (20 mg/kg, n = 6) [21-23].
Therefore, the Fade caused by antinicotinic (hexamethonium) agent may be severe (~ 89%) when the concentration of such agent is causing 25% [TOF.sub.fade] (Pereira, Sa, & Prado, 2012).
Although the decline after the 1950s can be partially explained by the development and use of drugs that effectively lowered blood pressure (i.e., hexamethonium, hydralazine, rauwolfia, and methyldopa), the reason for the decline previous to 1950 was unknown as of 1975 (Rosen 1975).
The preparations were preincubated with either atropine or hexamethonium and then exposed to [alpha]-hederin.
Similar to this finding, it has been showed that also the BP increase can be attenuated by pharmacological blockade of the autonomic nervous system with hexamethonium, indicating that it is mediated by the SNS rather than by mechanical factors related to changes in intrathoracic pressure.
The hexamethonium asthma study and the death of a normal volunteer in research.
An example occurred in summer 2001 when a volunteer on a Johns Hopkins research project died when she was given hexamethonium to inhale.
One of the most visible examples happened in summer 2001 when a volunteer on a Johns Hopkins research project died when she was given hexamethonium to inhale.
He enlisted healthy volunteers to inhale a chemical irritant, hexamethonium. One of the volunteers, a technician at the Johns Hopkins Asthma and Allergy Center, died.