hexobarbital


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hexobarbital

(ˌhɛksəˈbɑːbɪˌtæl)
n
(Pharmacology) a barbiturate with hypnotic and sedative properties
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There is evidence of clinically important drug-drug interactions between cannabis or cannabinoids and the following medications: chlorpromazine, clobazam, clozapine, CNS depressants (e.g., barbiturates, benzodiazepines), disulfiram, hexobarbital, hydrocortisone, ketoconazole, MAO inhibitors, phenytoin, protease inhibitors (indinavir, nelfinavir), theophylline, tricyclic antidepressants and warfarin.
The animals were placed on their backs on warmed (37[degrees]) pad and duration of loss of lighting reflex (starting at the time of hexobarbital injection) was measured until they regain their righting reflex.
Nebbia, "Lethality, hexobarbital narcosis and behavior in rats exposed to atrazine, bentazon or molinate," Research Communications in Chemical Pathology and Pharmacology, vol.
(1986) also reported inhibition of the AH, which suggested that the hexobarbital hydroxylase reduction was due to CP reduction.
Carbon tetrachloride (C[Cl.sub.4]) induced prolongation of hexobarbital sleeping time in mice: The mice are divided in to two groups of 10 animals each.
Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance.
Although neither serious adverse effect on central nervous system nor any morbidity has been reported in human so far, the clinical use of AL should also be with caution in patients with nervous problems due to its effects on various organ systems (general behavior and spontaneous movement, potentiation of hypnotic action of hexobarbital, and interference with muscle relaxation) [25, 51-56].