Perry and Miller  reported that candida albicans produces an enzyme [beta]-N-acetylgalactosaminidase and according to Rousselle et al,  incorporation of chromogenic or fluorogenic hexosaminidase
substrates into the growth media helps in identification of candida albicans isolates directly on primary isolation.
A hereditary defect in the hexosaminidase
A-subunit gene (HEXA, chromosome 15) or hexosaminidase
B-subunit gene (HEXB, chromosome 5) results in the absence of (HEX, E.C.184.108.40.206) isoenzymes.
Caqueret et al., "Mice doubly-deficient in lysosomal hexosaminidase
a and neuraminidase 4 show epileptic crises and rapid neuronal loss," PLoS Genetics, vol.
See Joel Zlotogora and Gideon Bach, "The Possibility of a Selection Process in the Ashkenazi Jewish Population," American Journal of Human Genetics, 73 (2003): 438-440; Ingrid Koo et al, "Role for Lysosomal Enzyme: Hexosaminidase
in the Control of Mycobacteria Infection," Proceedings of the National Academy of Sciences, 105 (2008): 710-715.
Speaking of accumulation, in Tay-Sachs disease a mutation for the protein hexosaminidase
A results in the failure to break down gangliosides (complex fat molecules).
Supplementary, mast cells granules contain sulphated proteoglycans (heparin in connective tissue mast cells or chondroitin sulphate in mucosal mast cells), histamine, serine proteases (cathepsin G, granzyme B, carboxypeptidase A3), Plasminogen activating factor, Platelet Activating Factor, eosinophils and neutrophils chemotactic factors, pglucuronidase, aryl-sulfatase, and hexosaminidase
The percentage of ([beta]- hexosaminidase
release in each tube was calculated and taken as a measure of mast cell activation.
Bacteria and fungi clades mostly contain one gene for hexosaminidase
in each species albeit few have two genes.
Simultaneously, 20 significant functional description nodes (P < 0.01) were found for group AS-Infla versus group BD-Infla, which included protein binding, nucleic acid binding, structure-specific DNA binding, RNA binding, and hexosaminidase
activity (Table 3).
Characterized by absence of hexosaminidase
A, an enzyme that breaks down GM2-ganglioside.
(23) Other enzymes like mannosidase, fucosidase, hexosaminidase
and sialidase also is elevated that expose buried adhesion receptors on mucosal epithelium thus increasing the adhesion of Gram negative bacteria this foster increased adhesion and colonization by respiratory pathogens.