Leeches have a substance in their saliva called Hirudin
that helps prevent blood clots in microsurgical procedures.
Rao, Chitosan/Polyethylene Glycol-Alginate Microcapsules for Oral Delivery of Hirudin
A study of Multiplate (Roche Diagnostics, Mannheim, Germany) samples showed decreased aggregation over time, but those samples were collected in hirudin
Randomized trial of intravenous heparin versus recombinant hirudin
for acute coronary syndromes.
A previous report indicated efficient secretory expression of recombinant hirudin
III in E.
Many studies have shown that leech and hirudin
have an antithrombotic effect.
Nowak G, Bucha E: A new method for the therapeutical monitoring of hirudin
In patients with HIT, heparin should be avoided to prevent recurrent HIT and PCI should be performed using alternative anticoagulants including direct thrombin inhibitors without cross-reactivity with HIT antibodies, such as argatroban, bivalirudin, and hirudin
Along with the natural anesthetic that helps dull the pain of their initial chomp, leeches release several compounds when feeding, including hirudin
, an anticoagulant that maintains blood flow during feeding; and calM, which inhibits clotting for a period afterward.
Abel and his colleagues used a substance known as hirudin
to prevent the blood from clotting.
The saliva of leech contains a local anaesthetic which limits the sensation of host, enzymes and anti-aglutination substances such as hirudin
(inhibits thrombin, factor IXa), antielastaze, antitripsine and antiplasmine which cause bleeding and anemia (El-Awad and Patil, 1990).
They use a combination of mucus and suction (caused by concentric muscles in those six segments) to stay attached and secrete an anti-clotting enzyme, hirudin
, into the host's blood stream3.