histocompatibility complex


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Noun1.histocompatibility complex - a family of fifty or more genes on the sixth human chromosome that code for proteins on the surfaces of cells and that play a role in the immune response
category, class, family - a collection of things sharing a common attribute; "there are two classes of detergents"
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References in periodicals archive ?
As a live attenuated bacterial vector, ADXS-NEO can be rapidly taken up by antigen presenting cells, which recognize it as foreign and present the tLLO-NEO fusion proteins to T cells by the major histocompatibility complex class I and II pathways.
Its proprietary T cell Antigen Coupler technology recruits the entire natural T cell receptor and is independent of the Major Histocompatibility Complex, allowing for the development of better therapies for a broader range of patients with solid or liquid malignancies and with diseases other than cancer.
Using its proprietary E-ALPHA[R] antibody discovery platform, Eureka developed a TCRm antibody to selectively bind an AFP peptide displayed on the cell surface by the HLA-A2 major histocompatibility complex (MHC).
Part of the National Institutes of Health (NIH), Dr Childs's laboratory will convert these antibodies into a CAR-T, as they work to develop a non-major histocompatibility complex (MHC) restricted immunotherapy approach to targeting an endogenous retrovirus with tumour-restricted expression.
In particular, major histocompatibility complex (MHC) genes, which regulate our immune systems, are thought to unconsciously influence mate choice.
Here, we report monitoring conservation effect on a Chinese indigenous chicken breed using major histocompatibility complex (MHC) and DNA barcords.
Carter and Marty's study centers on the Major Histocompatibility Complex (MHC), a family of molecules displayed on the surface of most cells in the body.
In allogeneic transplantation experiments, cardiac myocytes derived from monkey iPSCs with major histocompatibility complex homozygosity were shown to engraft into infarcted hearts and improve the cardiac function of heterozygous major histocompatibility complex-matched monkeys.[61] The immune response of the heterozygous major histocompatibility complex monkeys was favorable when transplantation involved cardiac myocytes derived from homozygous major histocompatibility complex-matched monkey iPSCs than from monkeys without identical major histocompatibility complex alleles.[62] These findings support the clinical rationale of allogeneic transplantation using major histocompatibility complex homozygous iPSCs.
An important role in the regulation of the immune response belongs to the molecules of the major histocompatibility complex of class I (HLA-I) and class II (HLA-II).
Success in this endeavour followed the discovery of the human major histocompatibility complex (MHC) in 1967.
Scientists from UEA and Dalhousie University studied how Guppy fish (Poecilia reticulata) adapt to survive by studying their immune genes, known as the Major Histocompatibility Complex or MHC genes.