histone


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his·tone

 (hĭs′tōn′)
n.
Any of several basic proteins found in association with the DNA in the chromatin of eukaryotes.

histone

(ˈhɪstəʊn)
n
(Biochemistry) any of a group of basic proteins present in cell nuclei and implicated in the spatial organization of DNA

his•tone

(ˈhɪs toʊn)

n.
any of a group of five small basic proteins, occurring in the nucleus of eukaryotic cells, that organize DNA strands into nucleosomes by forming molecular complexes around which the DNA winds.
[< German Histon (1884) = hist- of uncertain orig. + -on, perhaps after Pepton peptone]

his·tone

(hĭs′tōn′)
Any of several proteins that, together with DNA, make up most of the chromatin in a cell nucleus.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.histone - a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids
simple protein - a protein that yields only amino acids when hydrolyzed
Translations
histone
References in periodicals archive ?
Some histone modifications compact the DNA to hide a gene from the cell's protein-making machinery and consequently turn gene "off.
The histone H4 gene is supposed to be highly conserved among all organisms with the exception of variations found in the ciliate species.
Epigenetic mechanisms include changes in DNA methylation, histone modifications, and microRNA (miRNA) expression.
8 Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem
Researchers at Massachusetts General Hospital in Boston devised a tracer molecule that latches on to a protein that removes one type of epigenetic mark known as histone acetylation.
98) - Pipeline Review, H1 2016', provides in depth analysis on Histone Deacetylase 1 (EC 3.
Their topics include enzyme and protein families that regulate histone modification and cross-talk, targeting DNA methylation, targeting histone lysine methyltransferases in cancer, developments if targeting epigenetic readers, who will benefit from epigenetic drugs, histone methyltransferase activity assays, and safety considerations for epigenetic mechanisms as drug targets: whether existing toxicology studies are fit for the purpose.
announced today that Eisai has entered into an exclusive license agreement with HUYA Bioscience International, LLC (San Diego, CA, USA) to develop and market the oral histone deacetylase (HDAC) inhibitor HBI-8000 in Japan, South Korea, Thailand, Malaysia, Indonesia, Philippines, Vietnam and Singapore.
Histone acetylation plays an essential role in regulating gene expression [6,7].
Epigenetics, such as DNA methylation and histone modifications, are typically referred to as mitotically heritable changes in gene expression that do not involve any changes in DNA sequences [14].
In addition to methylation, epigenetic mechanisms that regulate gene transcription may also involve acetylation via histone acetyltransferases and histone deacetylases (HDACs), all of which act in a concerted fashion to determine the activity of a given gene.
Life sciences company VolitionRx (NYSE MKT:VNRX) reported on Thursday the receipt of the US patent entitled "Detection of Histone Modification in Cell-Free Nucleosomes", expiring in mid-2029.