Fatal reactive hemophagocytosis related to disseminated histoplasmosis
with endocarditis: an unusual case diagnosed at autopsy.
Three types of clinical disease may occur in patients with histoplasmosis
Prevention efforts targeting infection by other opportunistic pathogens include secondary prophylaxis with fluconazole (200-400 mg/day) for patients with a history of cryptococcal disease, and close monitoring of patients who live in areas of high histoplasmosis
prevalence, he stressed.
The following case presentation describes a patient with a history of chronic hepatitis C, cryoglobulinemia, renal failure and Staphylococcus aureus perinephric abscess and bacteremia, who, at autopsy, was found to have disseminated histoplasmosis
with fungal endocarditis and RHS.
1), (2) Elevated ACE levels are non-specific, however, and may be present in a wide variety of diseases including histoplasmosis
, cirrhosis, and tuberculosis.
He was reportedly treated for pericarditis, an inflammation of the sac that surrounds the heart, which was triggered by histoplasmosis
, a fungal infection of the lung.
Doctors diagnosed his illness as histoplasmosis
, a potentially life-threatening infection of the sac surrounding the heart.
Infected bats can spread rabies, and their droppings can spread organisms that cause the lung disease, histoplasmosis
To the Editor: Histoplasmosis
occurs after infection with the dimorphic fungus Histoplasma capsulatum (1-6).
Patients with histoplasmosis
or other invasive fungal infections may present with disseminated, rather than localized disease.
The endemic mycoses found in North America, namely, blastomycosis, coccidioidomycosis, and histoplasmosis
, are caused by thermally dimorphic fungi and can infect immunocompetent or immunocompromised hosts, often resulting in severe illness and death (1).
A 72-year-old African American woman with past mixed connective tissue disease (MCTD) with scleroderma-type features and recurrent histoplasmosis
presented with left forearm pain and mass.