holoenzyme


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Related to holoenzyme: apoenzyme

hol·o·en·zyme

 (hŏl′ō-ĕn′zīm′, hō′lō-)
n.
An active, complex enzyme consisting of an apoenzyme and a coenzyme.

holoenzyme

(ˌhɒləʊˈɛnzaɪm)
n
(Biochemistry) an active enzyme consisting of a protein component (apoenzyme) and its coenzyme

hol•o•en•zyme

(ˌhɒl oʊˈɛn zaɪm)

n.
an enzyme complete in both its apoenzyme and coenzyme components.
[1940–45]
References in periodicals archive ?
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.
The GCL holoenzyme consists of two separately coded proteins, a catalytic subunit (GCLC) and a modifier subunit (GCLM).
Differential regulation of glutamatecysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation.
At 72 hours post-exposure, apoptotic protein procaspase-3 holoenzyme was activated and cleaved the p17 cleavage product, which were both recognized by a caspase-3 antibody.
The apoenzyme activity was quantified as the difference between total and holoenzyme activities.
16] Further biochemical analysis of the R964C holoenzyme showed a 33% decrease in dTTP incorporation efficiency and a threefold decreased discrimination for d4TTP compared with the wild-type POLG1.
The homoplasmic15bp deletion results in abolishing the activity of COXI, COXII and COXIII subunits in holoenzyme as all the subunits are related and dependent on the COXIII subunit.
Recently, it has been shown that type I regulatory subunit I of PKA is subjected to oxidation by ROS on Cys 17 and 38, which leads to the intersubunit disulfide bond formation (between two regulatory subunits) and dissociation of the PKA holoenzyme complex.
Eukaryotes mainly use class la RRs, which comprise an [alpha]2/[beta]2 complex made up of two subunits a (termed R1) and [beta] (termed R2) that conglomerate to build the holoenzyme with the active form supposed to adopt [alpha]2[beta]2 quaternary state (Aye et al.
65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Fluorescence recovery assay: a continuous assay for processive DNA polymerases applied specifically to DNA polymerase III holoenzyme.