holoenzyme


Also found in: Medical, Encyclopedia, Wikipedia.
Related to holoenzyme: apoenzyme

hol·o·en·zyme

 (hŏl′ō-ĕn′zīm′, hō′lō-)
n.
An active, complex enzyme consisting of an apoenzyme and a coenzyme.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

holoenzyme

(ˌhɒləʊˈɛnzaɪm)
n
(Biochemistry) an active enzyme consisting of a protein component (apoenzyme) and its coenzyme
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

hol•o•en•zyme

(ˌhɒl oʊˈɛn zaɪm)

n.
an enzyme complete in both its apoenzyme and coenzyme components.
[1940–45]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
Xanthine oxidase is usually found as xanthine dehydrogenase and xanthine oxidase holoenzyme. The dehydrogenase form produces UA and the nicotinamide adenine dinucleotide, and the oxidase form produces UA and superoxide.
The 26S proteasome holoenzyme recognizes and processes poly-ubiquitinated substrates.
MOD_CDK_1 motifs matched with LVPTPGR (988-994) functional sites of the substrate motif for phosphorylation used by cyclin-dependent protein kinase holoenzyme complex in nucleus and cycloplasmic.
The tight association of Mediator with the CTD of Pol II forms Pol II holoenzyme, which is generally required for the transcription of most class II genes in vivo [7].
IDO is a holoenzyme containing a heme moiety that is functional only when the heme is reduced in the ferrous form by yet unidentified cofactors [20].
The CaMKII holoenzyme is comprised of 12-14 subunits [11-13] that permits coincident CaM binding to support an intraholoenzymeintersubunit autophosphorylation [14, 15] ([T.sup.286] a isoform and [T.sup.287] [beta], [gamma], and [delta] isoforms) reaction (for convenience, we use [T.sup.287] throughout the paper).
(1995) Conformational dynamics monitored by His-179 and His-200 of isolated thermophilic [F.sub.1]-ATPase [beta] subunit which reside at the entrance of the "conical tunnel" in Holoenzyme. FEBS Lett.
However, it is impossible to calibrate procedures for aminotransferases that do not incorporate P-5'-P using a procedure that does, such as the reference measurement procedure (RMP), because the ratio of preformed holoenzyme to apoenzyme differs among specimens (5).
The GCL holoenzyme consists of two separately coded proteins, a catalytic subunit (GCLC) and a modifier subunit (GCLM).
Differential regulation of glutamatecysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation.
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.
At 72 hours post-exposure, apoptotic protein procaspase-3 holoenzyme was activated and cleaved the p17 cleavage product, which were both recognized by a caspase-3 antibody.