homeobox


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ho·me·o·box

 (hō′mē-ə-bŏks′)
n.
A short DNA sequence contained within all homeobox genes that codes for a specific amino acid sequence that binds to DNA and regulates transcription.

[homeo(tic gene) + box (from the fact that the DNA sequence is short and when written can be enclosed by a box on paper).]

homeobox

(ˈhɒmɪəʊˌbɒks)
n
(Genetics) genetics a particular sequence of DNA found in genes that regulate cell development
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.homeobox - one of various similar homeotic genes that are involved in bodily segmentation during embryonic development
homeotic gene - one the genes that are involved in embryologic development
References in periodicals archive ?
2 kd protein 41 [P36053] AI376340 LIM homeobox protein [Z97340] 29 AA080651 ribosomal protein L30 [B24028] 34 AA080653 alpha-fetoprotein enhancer-binding 8 protein [A41948] AA080669 mouse B-cell receptor CD22-Beta 7 precursor [P35329] AA080671 influenza virus hemagglutinin 5' 21 epitope tag [S71745] AA080672 erythrocyte membrane protein band 14 4.
Having identified the homeobox segment, researchers searched for it in other organisms.
Consider the explanation that is often given for surprisingly deep and widespread homologies, such as the well known homologies in tetrapod skulls that derive from embryonic gill arches, or the newly discovered molecular homologies in the homeobox gene systems among all metazoa.
In experiments at the ARS/University of California Plant Gene Expression Center at Albany, Hake discovered the first-ever homeobox in plants.
Bickels syndrome, mucolipidoses, cherry-red-spot-myoclonus syndrome, inclusion-cell disease, growth-hormone deficiency, idiopathic short stature, small for gestational age (SGA), acromegaly, AIDS-associated wasting and cachexia, growth failure from chronic renal insuffi ciency (CRI), Noonans syndrome, Prader-Willis syndrome, short stature homeobox (SHOX) defi ciency, Turners syndrome, obesity, type 1 and type 2 diabetes.
They commonly show at least focal CK20 and caudal-related homeobox gene 2 (CDX2) positivity and express markers of pyloric-type mucin (MUC6 and HIK1083), (34-36) and may be only focally positive or negative for PAX8 immunostain (Figure 7, A through F).
The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation.
sup][35] Overexpression of miR-144 led to a reduction in TGF-[sz]-induced factor homeobox 1 and an increase in profibrotic factors whereas knockdown of miR-144 diminished fibrogenesis.
These diseases are believed to have a genetic basis and have been linked to mutations and/or deletions in the double cortin (DCX), filamin-1, LISI, reelin (RENL), tubulin (TUBA1A), and aristaless-related homeobox (ARX) genes, (DOBYNS et al.
An important role in genesis of Schizencephaly is mutation in homeobox gene EMX2, a gene coding for transcription factor involved in expression of the gene.
In addition to these, one important mediator is the homeobox gene pitx2, which expressed asymmetrically in the left lateral plate mesoderm (LPM), tubular heart and early gut tube (Campione et al.
In the current assembly of the Ciona genome, 341 transcription factor genes of well-known classes, including bHLH, bZIP, homeobox, nuclear receptor, T-box, Ets, HMG, and zinc fingers that are annotated as transcription factors, and additional 297 zinc-finger genes that might encode transcription factors, have been comprehensively listed up (12-19) (http:// ghost.