Primers for the genes tested [Ahr, Cx40 (connexin 40), Cyplal (cytochrome P450 1A1), Ece1 (endothelin converting enzyme 1), Gata4 (GATA-binding protein 4), Gata6 (GATA-binding protein 6), Hcn4 (hyperpolarization-activated, cyclic nucleotidegated K+ 4), Kdr (kinase insert domain protein receptor), Mef2c (myocyte enhancer factor 2C), Mlc2v (myosin, light polypeptide 2, regulatory, cardiac, slow), Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha), Myh7 (myosin, heavy polypeptide 7, cardiac muscle, beta), Nanog (Nanog homeobox
), Nkx2-5 (NK2 homeobox
5), Nppa (natriuretic peptide type A; Anf), Oct4 (POU domain, class 5, transcription factor 1; Pou5f1), Pgp9.
0); steamer Antibody Detection System TTF-1 Envision Flex Link HRP-DAB (Dako) 34[beta]E12 HMK Envision Flex Link HRP-DAB (Dako) N-cadherin Envision Flex Link HRP-DAB (Dako) CDX2 Envision Flex Link HRP-DAB (Dako) IMP3 Envision Flex Link HRP-DAB (Dako) Napsin A Envision Flex Link HRP-DAB (Dako) Abbreviations: 34[beta]E12, high-molecular-weight cytokeratin; CDX2, caudal type homeobox
2; HMK, high-molecular-weight keratin; HRP-DAB, horseradish peroxidase-3,3'diaminobenzidine tetrahydrochloride dihydrate; IMP3, insulin-like growth factor II MRNA-binding protein 3;N-cadherin, neural cadherin; TRS, target retrieval system (Dako); TTF-1, thyroid transcription factor-1.
1) is a homeobox
gene with mutations that effect second premolars and third molars with an association for cleft lip and/or palate and Witkop syndrome (Zhang et al.
Roles of the middle domain-specific WUSCHEL-RELATED HOMEOBOX
genes in early development of leaves in Arabidopsis.
Four candidate markers, insulin-like growth factor 1 (IGF-1), human telomerase reverse transcriptase (hTERT), BLCA-4 and homeobox
A13 (HOXA13) showed greater upregulation in stage Ta to T1 tumours than in stage >T1 tumours, with the greatest differential expression of BLCA-4 and HOXA13.
Chromosomal translocation t(1;19) results in synthesis of a homeobox
fusion mRNA that codes for a potential chimeric transcription factor.
The NKX2-5 (NK type homeobox
) is a NK-2 homeobox
containing transcription factor which is required for heart development.
That this is indeed the case is substantiated by experiments in the baboon model, where induction of endometriosis and chronic inflammation resulted in a gradual decrease--over 6 to 12 months--in endometrial expression of a homeobox
transcription factor involved in endometrial development named HOXA-10 (81).
Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox
expression in muscle lineage of the gastropod Haliotis asinina: evidence for a conserved role in bilaterian myogenesis.
Advances in the field of genetics have estimated that about 2% of idiopathic short stature is related to haplo-insufficiency of the short stature homeobox
(SHOX) gene, which is found on the short arm of the X and Y chromosomes in the pseudo-autosomal region.
Table 1: Human Chromosomes Responses to Low Levels of Mercury PROUE SET Gene Title (target Chromosome Location ID Dcscription)/symbol 207009_at Paired-like homeobox
2b; PHOX2B 4p12 HGNC; 6355 regulation of transcription, DNA dependent; 7275 development; 7399 neurogenesis; 5634 nucleus; 3700 transcription factor activity; 3712 transcription cofactor activity.