homeobox


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ho·me·o·box

 (hō′mē-ə-bŏks′)
n.
A short DNA sequence contained within all homeobox genes that codes for a specific amino acid sequence that binds to DNA and regulates transcription.

[homeo(tic gene) + box (from the fact that the DNA sequence is short and when written can be enclosed by a box on paper).]

homeobox

(ˈhɒmɪəʊˌbɒks)
n
(Genetics) genetics a particular sequence of DNA found in genes that regulate cell development
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.homeobox - one of various similar homeotic genes that are involved in bodily segmentation during embryonic development
homeotic gene - one the genes that are involved in embryologic development
References in periodicals archive ?
Kojis et al., "Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1," Genomics, vol.
The most notable genes that differed are known as homeobox genes.
Discovered first in 1983 by Ernst Hafen et al in the university of Basel, Switzerland, Homeobox genes are an evolutionary conserved class of transcription factors that are key regulators during developmental processes such as regional specifications, patterning and differentiation.
determinaron que las mutaciones en el gen ZEB2 (Zinc finger E-boxbinding homeobox 2) (4), eran las responsables de esta enfermedad dada la importancia de esta proteina durante el proceso de embriogenesis (5).
Se han realizado estudios de mutaciones en ratones transgenicos de genes involucrados en el desarrollo dental como son la familia de genes Homeobox, BMP, FGF, Wnt y Shh, donde se ha encontrado asociacion con agenesia, especificamente en la detencion de la etapa de iniciacion los genes Msx1, Msx2, Dlx1, Dlx2, Fgf8, Lhx6/ Lhx7, Pitx2, Gil2, P63, Dkkl, y en la etapa de brote Pax9, Lef1, Max1, Runx2, Barx1, Bmpr1a, Fgfr2b, Shh, Noggin (1).
HHEX, Hematopoietically expressed Encodes a member of the homeobox homeobox (10) family of transcription factor involved in pancreatic development.
Gene Accession Primer sequences number (GeneBank) Preproinsulin X_M003508080.1 5'-CTTTTGTCAAACAGCACCTTTGTG- 3' (sense) 5'-TCAGTTGCAGTAGTTCTCCAGTTGG- 3' (antisense) PDX-1 XM_003496658.1 5'-CAGCTCCCTTTCCCGTGG A- 3' (sense) 5'-GAGCATCACTGCCAGCTCCA- 3' (antisense) Nrf2 XM_003498316.1 5'-CTCACTGGATAAAGAAGTC- 3' (sense) 5'-CCGCCCAGAAGTTCAGAGA- 3' (antisense) [beta]-Actin NM_031144.2 5'-AAGAGAAGCTGTGCTATGTTGC- 3' (sense) 5'-CCTTGATCTTCATGGTGCTAGG- 3' (antisense) Gene Product Annealing Number of size (bp) temperature cycles ([degrees]C) Preproinsulin 263 48 25 PDX-1 204 55 28 Nrf2 240 60 40 [beta]-Actin 324 48 25 PDX-1, Pancreatic and duodenal homeobox 1; Nrf2, Nuclear factor (erythroid-derived 2)-like 2.
Moreover, ARP genes antagonize WUSCHEL and Class 1 KNOTTED1-LIKE HOMEOBOX (KNOX1) genes (Waites et al., 1998; Timmermans et al., 1999; Ori et al., 2000; Venglat et al., 2002; Zgurski et al., 2005; Katayama et al., 2010), that promote meristem indeterminacy and maintain proximal cell division in leaf development after this has ceased in more distal areas (Byrne et al., 2000, 2002).
The human genome has the ability of guiding tissue differentiation via the homeobox genes.
Additional genes of importance include CXCR6, prospero homeobox 1 (PROX1), an intergenic SNP between ribosomal protein S6 kinase alpha-6 (RPS6KA6) and cylicin-1 (CYLC1) genes (X chromosome).
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome.
The NKX2-5 (NK type homeobox) is a NK-2 homeobox containing transcription factor which is required for heart development.