and synergy: pathways and mechanisms of quercetin in cancer prevention and management.
Este efeito, conhecido como hormesis
, ou efeito hormetico (CALABRESE; BALDWIN, 2002), foi introduzido por Southam e Erlich (1943) e vem sendo amplamente discutido e pesquisado com o objetivo de se compreender o mecanismo de acao estimulante e benefico de diversas substancias, inicialmente consideradas toxicas ou inibitorias em doses elevadas (CEDERGREEN; OLESEN, 2010; CARVALHO; ALVES; DUKE, 2013; BELZ; DUKE, 2014).
We propose that longevity promotion under conditions of Se deficiency may be attributed to 1) stress-response hormesis
, an advantageous event of resistance to toxic chemicals at low doses; 2) reduced expression of selenoproteins with paradoxical functions to a lesser extent.
Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis
Beyond energy production, which mitochondria are most known for, Ray Griffiths takes us through the history and origin (from bacterial, parasitic invaders, to allies that have co-evolved), mitochondrial dynamics (how they sustain efficiency and mobility), their ability to be a hybrid engine when presented with fats or carbohydrates, ketone metabolism, immune regulation, calcium storage and regulation, control center for apoptosis, heme production, kidney detoxification and hormone synthesis, and their need for a touch of hormesis
(biphasic dose response to a toxicant) in order to improve form and function.
Exercise is also a form of hormesis
. The most important reason why exercising is healthy is because it damages the body.
We conclude that the Revisers must be strong followers of the hormesis
Several factors are identified as responsible for outbreaks, such as the banning of some broad spectrum insecticides and acaricides, frequent dry spells, use of new varieties with characteristics that may favor the development of mite populations, and the hormesis
effect caused by new pesticides (Guedes & Cutler 2014; Guedes et al.
5), it was observed a root increase at 1 and 100 mg x [kg.sup.-1] doses, followed by a negative effect on the highest doses (5,000 and 10,000 mg x [kg.sup.-1]), characterizing hormesis
It resembles the effect of hormesis
that occur in plants adapted to stressors by exposure to a pollutant during long periods of the life cycle (Calabrese, Baldwin, & Holland, 1999).
Beyond selectivity: Are behavioral avoidance and hormesis
likely causes of pyrethroid-induced outbreaks ofthe southern red mite Oligonychus ilicis?
These models may, however, not fit the measured data very well and they are often criticized due to their marginalization of hormesis
(Calabrese, 2007, 2009).