TNX-801 (live virus vaccine for percutaneous (scarification) administration) is a potential smallpox-preventing vaccine based on a live synthetic version of horsepox
virus, currently in the pre-IND application stage.
Altogether, 212/214 predicted proteins had results in the nonredundant database; most (191) best-hit results were obtained for cowpox virus from various previously described strains, 9 for vaccinia virus, 4 for variola virus, 3 for monkeypoxvirus, 2 for ectromelia virus, and 1 each for horsepox
, camelpox, and taterapox.
They have already done it with horsepox
, which is not very different from variola virus.
In January, a small research team at the University of Alberta engineered a cousin of the lethal smallpox virus called horsepox
, using strands of DNA they received in the mail.
Researchers from the University of Alberta produced an infectious horsepox
virus, which they synthetically reconstructed using a published genome sequence and DNA fragments manufactured entirely by chemical methods.