human artificial chromosome


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human artificial chromosome

n.
A large DNA sequence constructed in the laboratory to function like a human chromosome.
References in periodicals archive ?
Stem cell-mediated transfer of a human artificial chromosome ameliorates muscular dystrophy.
Natalay Kouprina of the US National Cancer Institute in Bethesda, Maryland, who is a part of the team that successfully created genetically engineered mice with an extra human artificial chromosome in their cells, told the Independent that it is the first time such an advanced form of a synthetic human chromosome built 'from scratch' has been shown to work in an animal model.
The human artificial chromosome survived for as long as 6 months in cells, retaining its integrity while replicating during many cell divisions, Willard and his team report in the April Nature Genetics.

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