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Related to hyalinosis: malalignment, transvesical


n. hialinosis, degeneración hialina.
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Furthermore, the kidney of diabetic rats showed somewhat arterial hyalinosis and vascular hypertrophy (A).
1929 mucosae." [1, 2] It has been known by several terms such as "Urbach-Weithe disease," "lipoglycoproteinosis," "lipid proteinosis," and "hyalinosis cutis et mucosae." [3, 4] Molecular genetic studies of LP patients have revealed that mutations in the ECM1 gene located on chromosome 1q21.2 are responsible for this disease.
Five of the 45 with prevalence of 10% or greater had agreement estimates greater than 0.6 using the Cohen [kappa] (Figure 5, a), including 1 individual descriptor (segmental hyaline droplets in epithelial cells), 3 subclasses (tip lesion, segmental hyalinosis, and podocyte hyaline droplets), and 1 class (podocyte injury).
CNI nephrotoxicity can manifest as interstitial fibrosis/tubular atrophy (IF/TA) and arteriolar hyalinosis. CNIs are also less effective at preventing chronic alloantibody responses than they are at limiting acute T cell mediated responses, leading to a risk of donor specific antibody (DSA) development and chronic antibody mediated rejection [4].
The first biopsy (04/2003) showed borderline rejection with interstitial edema and mild vascular rejection, but the following biopsies showed mainly chronic changes with signs of nephrosclerosis, arteriolar hyalinosis, and increasing interstitial fibrosis and tubular atrophy (07/2003, 11/2005, and 08/2009).
The characteristic light microscopic features of diabetic nephropathy comprise three major lesions: thickened glomerular basement membranes (GBM) and tubular basement membranes, diffuse mesangial expansion, and hyalinosis of afferent and efferent arterioles.
A subsequent renal biopsy showed focal segmental glomerulosclerosis (FSGS) in two of twelve viable glomeruli, with tuft-capsule adhesion, hyalinosis, segmental intracapillary hypercellularity, and segmental splitting of capillary walls, predominantly in regions of segmental sclerosis.
Diabetic nephropathy including nodular sclerosis and arteriolar hyalinosis is seen in the background (Figure 4).
Interestingly, efferent arteriolar hyalinosis was reported that specific kidney changes to DKD had a clear correlation with urine albumin excretion and disease progression.[sup][8],[9],[10] However, there was still lack of proofs to confirm that vascular lesions were directly associated with the prognosis of DKD.
Lipoid proteinosis is also known as hyalinosis cutis et mucosae, Urbach-Wiethe disease.
Histological examination of the circumcision tissue usually confirms the diagnosis, showing hyperkeratosis with follicular plugging, atrophy of the stratum spongiosum Malpighi with hydropic degeneration of basal cells, lymphedema, hyalinosis and homogenization of collagen in the upper-dermis, and inflammatory infiltration in the mid-dermis.
Chronic NFAT downregulation leads to hyalinosis of the renal vasculature, tubular atrophy and fibrosis, and glomerular thickening with either segmental or diffuse sclerosis.