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Related to hyaluronidase: hyaluronic acid


 (hī′ə-lo͝o-rŏn′ĭ-dās′, -dāz′)
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.


(ˌhaɪəlʊˈrɒnɪˌdeɪs; -ˌdeɪz)
(Biochemistry) an enzyme that breaks down hyaluronic acid, thus decreasing the viscosity of the medium containing the acid
[C20: hyalo- + Greek ouron urine + -id3 + -ase]


(ˌhaɪ ə lʊˈrɒn ɪˌdeɪs, -ˌdeɪz)

an enzyme that decreases viscosity in the tissue spaces of the body by breaking down hyaluronic acid: used as an ingredient for diffusing injected drugs.
[1935–40; hyaluron(ic acid) + -id- + -ase]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hyaluronidase - an enzyme (trade name Hyazyme) that splits hyaluronic acid and so lowers its viscosity and increases the permeability of connective tissue and the absorption of fluids
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
References in periodicals archive ?
The paper 'Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype' is published in the journal Science Signalling.
The Halozyme Enhanze technology is based on a proprietary recombinant human hyaluronidase enzyme (rHuPH20) that temporarily degrades hyaluronan -- a glycosaminoglycan or chain of natural sugars in the body -- to aid in the dispersion and absorption of other injected therapeutic drugs, which may allow for more rapid delivery of injectable medications through subcutaneous injection.
It has the power to inhibit the enzyme hyaluronidase, which is known as the 'spreading factor'; this is secreted by micro-organisms and is a component of snake venom, its purpose is to break down the ground substance, the intracellular cement that holds body cells together, thereby allowing the toxin to spread throughout the body.
Hyaluronidase is an enzyme that can degrade HA and is particularly useful to treat complications of HA use such as superficial/ uneven placement, granulomatous reactions and skin necrosis.
If HA filler was used, then hyaluronidase should be injected in and around the treatment location.
Background: Hyaluronidase is part of extracellular bacterial structure that degrade hyaluronic acid, hyaluronidases event by [BETA] elimination of the [BETA]-1,4 glycosidic bond in hyaluronic acid .
ENHANZE is based on a recombinant human hyaluronidase enzyme (rHuPH20) that temporarily modifies hyaluronan to aid in the dispersion and absorption of other injected drugs.
What's more, Liquid BioCell even goes a step further and reduces hyaluronidase, the enzyme that makes your skin age.
They have supplied facilities like ours with hyaluronidase for more than a decade now without a hitch.
Tests indicated that a 97% inhibition of hyaluronidase was achieved with the use of AquaMax at a concentration of 0.
Hyaluronidase inhibition assay was studied in vitro using bovine testicular hyaluronidase and human umbilical cord hyaluronic acid.