hyaluronidase


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Related to hyaluronidase: hyaluronic acid

hy·a·lu·ron·i·dase

 (hī′ə-lo͝o-rŏn′ĭ-dās′, -dāz′)
n.
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

hyaluronidase

(ˌhaɪəlʊˈrɒnɪˌdeɪs; -ˌdeɪz)
n
(Biochemistry) an enzyme that breaks down hyaluronic acid, thus decreasing the viscosity of the medium containing the acid
[C20: hyalo- + Greek ouron urine + -id3 + -ase]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

hy•a•lu•ron•i•dase

(ˌhaɪ ə lʊˈrɒn ɪˌdeɪs, -ˌdeɪz)

n.
an enzyme that decreases viscosity in the tissue spaces of the body by breaking down hyaluronic acid: used as an ingredient for diffusing injected drugs.
[1935–40; hyaluron(ic acid) + -id- + -ase]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hyaluronidase - an enzyme (trade name Hyazyme) that splits hyaluronic acid and so lowers its viscosity and increases the permeability of connective tissue and the absorption of fluids
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
This subcutaneous formulation of daratumumab is co-formulated with recombinant human hyaluronidase PH20 (rHuPH20) [Halozyme's ENHANZE drug delivery technology].
According to the company, the subcutaneous formulation of DARZALEX is co-formulated with recombinant human hyaluronidase PH20 (rHuPH20) [Halozyme's ENHANZE drug delivery technology].
Kirsty Collins, 33 - who is known as Bambi Black to fans - paid [pounds sterling]300 to have her lips injected with hyaluronidase to remove her existing filler so she could start all over again.
This new treatment includes the same monoclonal antibody as intravenous Herceptin[R] (trastuzumab) in combination with recombinant human hyaluronidase PH20, an enzyme that helps to deliver trastuzumab under the skin.
This new treatment includes the same monoclonal antibody as intravenous Herceptin in combination with recombinant human hyaluronidase PH20, an enzyme that helps to deliver trastuzumab under the skin.
LOW DOSES OF HYALURONIDASE appear to be effective at eliminating unwanted hyaluronic acid filler, and in some cases, slightly larger doses may move things along more rapidly, according to the authors of a small split-arm clinical trial.
THURSDAY, April 26, 2018 (HealthDay News) -- Very low doses of hyaluronidase can remove hyaluronic acid filler nodules, but more rapid resolution is seen with slightly higher doses, according to a study published online April 25 in JAMA Dermatology.
The paper 'Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype' is published in the journal Science Signalling.
Moreover, the staining disappeared after hyaluronidase digestion, suggesting that the tumor contained abundant hyaluronan (Figures 1(c) and 1(d)).
Hyaluronidase is an enzyme that can degrade HA and is particularly useful to treat complications of HA use such as superficial/ uneven placement, granulomatous reactions and skin necrosis.
The Journal would like to correct the order of the authors for correspondence in the article "Primary cultures of mouse small intestinal epithelial cells using the dissociating enzyme type I collagenase and hyaluronidase" that was published incorrectly in volume 50 no.