hybridoma


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hy·brid·o·ma

 (hī′brĭ-dō′mə)
n.
A cell that is produced in the laboratory by fusing an antibody-producing lymphocyte (which does not readily divide) with a nonantibody-producing cancer cell (which divides rapidly). The hybridoma proliferates and produces a continuous supply of a specific monoclonal antibody.

hybridoma

(ˌhaɪbrəˈdəʊmə)
n
(Biochemistry) a hybrid cell formed by the fusion of two different types of cell, esp one capable of producing antibodies, but of limited lifespan, fused with an immortal tumour cell
[C20: from hybrid + -oma]

hy•brid•o•ma

(ˌhaɪ brɪˈdoʊ mə)

n., pl. -mas.
a hybrid cell made in the laboratory by fusing a normal cell with a cancer cell, usu. a myeloma or lymphoma, in order to combine desired features of each, as the ability of the cancer cell to multiply rapidly with the ability of the normal cell to dictate the production of a specific antibody.
[1975–80]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hybridoma - a hybrid cell resulting from the fusion of a lymphocyte and a tumor cell; used to culture a specific monoclonal antibody
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";
Translations
hybridome

hy·brid·o·ma

n. hibridoma, célula somática híbrida capaz de producir anticuerpos.
References in periodicals archive ?
We extracted mRNA from tacrolimus 1-60-46 hybridoma cell line (Abbott Laboratories code 93339) using Oligotex direct mRNA isolation kit (Qiagen).
Compared to currently available antibody technology on the market, such as mouse hybridoma, the company's proprietary technology can generate RabMAbs more efficiently and that have superior binding affinity and bioactivity in a wide variety of biological assays.
Serologicals Corporation (NASDAQ: SERO) has announced that Celliance Corporation, its wholly-owned subsidiary, has introduced Hybri-CYTE(tm), a serum-free cell culture supplement designed and optimized for use in hybridoma cell culture that has been proven to work with mouse, rat and rabbit derived cell-lines.
Survival of HT-22 hippocampal hybridoma culture cells was measured via the MTT colorimetric assay.
Murine monoclonal dinitrophenyl (DNP)-specific IgE was obtained from the culture of hybridoma Hi-DNP-[epsilon]-26.
coli, CHO, various yeasts, human and mouse hybridoma cell lines.
Army Medical Research Institute of Infectious Diseases, where she supervises the Cell Culture and Hybridoma Production facilities.
The hybridoma cells were resuspended in 90 mL of Iscove's modified Dulbecco's medium (Sigma Chemical Company) (IMDM) containing 200 [[micro]liter] [mL.
The antibodies are produced by a laboratory cell culture of fused mouse spleen and myeloma cells called a hybridoma.
With the advent of hybridoma technology in 1975, immunologists could prepare almost unlimited quantities of antibodies.
Biochemists then test the monoclonal antibodies of each hybridoma to see which, if any, hasten the reaction.