hydroxylase


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hydroxylase

(haɪˈdrɒksɪˌleɪz)
n
(Biochemistry) an enzyme useful in hydroxylation
References in periodicals archive ?
Background: Phenylalanine hydroxylase (PAH) gene is the well-known causative gene for classic Phenylketonuria (PKU) (OMIM#261600) disease, with more than 500 reported mutations.
Genetic 21 hydroxylase deficiency and deletion in CYP21A2 gene in line with salt depletion form were detected in patients for whom hydrocortisone, mineralocorticoid and salt replacement treatment were started.
9) The progesterone level was high, but 17 hydroxy progesterone was undetectable because of the absence of 17 hydroxylase activity.
After PB treatment, the activities of cytochrome p-450 (CP), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphatamine demethylase (BD), aminopyrine demethylase (APD) and N.
Tyrosine hydroxylase (TH) was not expressed in tumor tissue compared to normal adrenal gland medulla (Fig.
Initial results indicate that haplodeficiency of the oxygen sensor HIF-prolyl hydroxylase 2 (PHD2) in tumor and stromal cells reduced metastasis by 80% in a clinically relevant spontaneously arising PyMT BC mouse model.
CAH due to 21 hydroxylase deficiency is one of the most common autosomal recessive hereditary diseases.
Other enzymes like 11-beta hydroxylase and 3- beta hydroxysteroid dehydrogenase deficiency can also cause CAH which is rare.
Little Oranye Chimweokwu Sayne was brought to Max Super Speciality Hospital, Shalimar Bagh recently where she was diagnosed with a rare genetic disorder called Congenital Adrenal Hyperplasia whereby the body does not produce the vital 21- hydroxylase enzyme leading to enlargement of the clitoris.
It was discovered that calcitriol activates the transcription of tryptophan hydroxylase 2, a gene that converts the amino acid tryptophan to serotonin in the brain.
Ames demonstrated that vitamin D hormone activates the gene that makes the enzyme tryptophan hydroxylase 2 (TPH2), which converts the essential amino acid tryptophan into serotonin in the brain.
Of special interest to the researchers were: 1) the mice's locomotor activity in response to cocaine; 2) the degree of conditioning for place preference; 3) electrical activity of the ventral tegmental area (part of the brain's reward system; it plays a role in sense of euphoria and well-being); 4) the presence of tyrosine hydroxylase in the VTA; and 5) the presence of deoxyribonucleic acid (DNA) sequences for the Clock gene in the brain.