hydroxylate


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Related to hydroxylate: hydrolyze, Venturi effect

hy·drox·yl·ate

 (hī-drŏk′sə-lāt′)
tr.v. hy·drox·yl·at·ed, hy·drox·yl·at·ing, hy·drox·yl·ates
To introduce hydroxyl into (a compound).

hy·drox′y·la′tion n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

hydroxylate

(haɪˈdrɒksɪˌleɪt)
vb (tr)
(Chemistry) to introduce hydroxyl into a chemical compound
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Pharmacokinetics of edibles indicate cannabinoids are introduced through the gastrointestinal tract where THC is absorbed into the bloodstream and travels via the portal vein to the liver where liver enzymes (primarily Cytochrome P450) hydroxylate THC to form 11-hydroxytetrahydrocannabinol (11-OH-THC).
(4) Vitamin C helps to hydroxylate excess proline and lysine in procollagen, stabilizing the triple helix.
The spectrum clearly shows a broad absorption around 3400 [cm.sup.-1], which was a characteristic stretching vibration of hydroxylate (0-H).
Hsu et al., "The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands," The Journal of Biological Chemistry, vol.
The PHD1 and PHD2 hydroxylate HIF-[alpha] isoforms and loss-of-function mutations in their genes (PHD1 and PHD2) cause an excess of HIF-[alpha] and its proneoplastic actions [17, 42].
Under normoxic conditions, PHDs hydroxylate specific proline residues in the hypoxia-inducible factors (HIFs), which are then polyubiquitinated by von Hippel-Lindau E3 ubiquitin ligase complex and degraded by the proteasome.
Insect POs are artificially divided into tyrosinase-type POs and laccase-type POs in some reports: the former can hydroxylate monophenols to o-diphenols (EC 1.14.18.1) and then oxidize the o-diphenols to quinones (EC 1.10.3.1), but it cannot oxidize p-diphenols; the latter lack the monophenol monooxygenase activity but can oxidize both o- and pdiphenols (EC 1.10.3.2) [53, 54].
This oxygen bound ferrous heme of NOS can preferentially receive one more electron from B[H.sub.4], enabling NOS to hydroxylate L-arginine to initially form Nwhydroxyl-l-arginine that is ultimately oxidized to NO and Lcitrulline.
The processes are mainly performed by microbes that hydroxylate phenols at the second carbon position [35].
Also, ascorbic acid is found to affect the activity of prolyl hydroxylases, rough endoplasmic reticulum enzymes that hydroxylate proline residues in nascent procollagen chains and allow folding of the chains into stable triple helix [25].
Two columns of polymethyl methacrylate hydroxylate (Waters Ultrahydrogel 1000 and Ultrahydrogel 500), with respective exclusion volumes of 1.0 x [10.sup.6] and 8.0 x [10.sup.4] Da, were connected in series.
Hanauske-Abel explains that ciclopirox and deferiprone both inhibit a cellular protein called deoxyhypusine hydroxylate (DOHH) in CD4 positive cells, which slows their replication.