hydroxyurea


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hy·drox·y·u·re·a

 (hī-drŏk′sē-yo͝o-rē′ə)
n.
An antineoplastic drug, CH4N2O2, that suppresses the production of blood cell precursors in the bone marrow and is used in the treatment of certain leukemias, carcinomas, and sickle cell anemia.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

hydroxyurea

(haɪˌdrɒksɪjʊˈrɪə)
n
(Medicine) a drug which prevents the development of tumours and is used in the treatment of certain types of cancer as well as in the treatment of sickle-cell disease and AIDS
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
Translations

hydroxyurea

n hidroxiurea, hidroxicarbamida (INN)
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
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References in periodicals archive ?
Mr Al Kadhem said the issue came to his notice when he realised that sickle cell patients had the habit of stocking up on large quantities of medicines, especially heavy painkillers such as hydroxyurea.
In this mid-stage trial, the monoclonal antibody at 5mg/kg was indicated to have decreased the median annual rate of vaso-occlusive crises leading to health care visits by 45.3%, in comparison to placebo in patients with or without hydroxyurea. Also, clinically significant decrease were observed in the crizanlizumab arm in the frequency of vaso-occlusive crises among patients, irrespective of sickle cell disease genotype or hydroxyurea use in the SUSTAIN trial.
Jakafi is also indicated for treatment of polycythemia vera in adults who have had an inadequate response to or are intolerant of hydroxyurea as well as intermediate or high-risk myelofibrosis, including primary MF, post-polycythemia vera MF and post-essential thrombocythemia MF in adults.
Hydroxyurea, with its inhibitory effect, can reduce the synthesis of DNA and can therefore lead to cell death [21].
We assessed whether the reactions of leukemic cells to imatinib, hydroxyurea, and HDACi are affected variably by hPL and FCS.
Apart from Hydroxyurea, which other medication do you take?
This European approval makes Besremi the first and only approved treatment for polycythemia vera (PV) independent of previous hydroxyurea exposure based on Phase III clinical data.
Stimulation of HbF production, with drugs such as hydroxyurea, (8) butyrate, (9) 5-aza-2-deoxycytidine, (10) has been shown to ameliorate the clinical severity of SCD by interfering with the polymerization of deoxygenated HbS in vitro.
Medunik USA announced that Siklos (hydroxyurea), the first and only FDA-approved hydroxyurea-based treatment for pediatric patients with sickle cell anemia, is now available through the Siklos At Home program.
In both trial groups, two-thirds of patients received concomitant hydroxyurea. The L-glutamine group more often had low-grade nausea, non-cardiac chest pain, fatigue, and musculoskeletal pain.
Currently, the mainstay of treatment for SCD is hydroxyurea, which has been shown to decrease the number and severity of painful crises and to increase survival time.