Type II of familial hyperaldosteronism
was first described in an Australian family 25 years ago.
The various causes of hypoKPP include thyrotoxicosis, use of diuretics, distal RTA (dRTA)(6%), Gitelman syndrome, liquorice consumption, and primary hyperaldosteronism
Secondary forms are more common and are the result of acquired hypokalemia such as thyrotoxicosis, hyperaldosteronism
, diabetic ketoacidosis, diarrhea, vomiting, drugs or RTA.
6,9 The panel of investigations requires specific tests for pheochromocytoma, Cushing's syndrome in all patients, for primary hyperaldosteronism
in hypertensive patients with and/or hypokaliaemia.
Serum potassium and plasma aldosterone level was done in suspected primary hyperaldosteronism
Conditions such as pheochromocytoma, hyperaldosteronism
and renovascular hypertension require specific individual anesthesiologic approach (4).
Were causes of AHT other than the mitochondrial DNA variant, such as hyperthyroidism, renal artery stenosis, renal parenchymatous disease, hyperaldosteronism
, or pheochromocytoma, excluded as alternative causes of AHT?
The R563Q [beta]-ENaC mutation and primary hyperaldosteronism
together were responsible for >50% of cases of secondary hypertension in our study.
The measurement of plasma renin activity and aldosterone and the results of a 1-mg overnight dexamethasone suppression test ruled out primary hyperaldosteronism
and Cushing syndrome.
Initially considered to be rare, hyperaldosteronism
is found in approximately 6% of all hypertensive human patients and accounts for 11% of those with hypertension non- responding to therapy (FOGARI et al.
is caused due to an excess production of aldosterone, may be primary or secondary in origin (Feldman and Nelson, 2004).
09 nmol/L, the combination indicating a state of secondary hyperaldosteronism