Its symptoms include severe pain, hyperalgesia
, numbness, impairment of equilibrium and muscle movements, burning pain and pricking pain.
The groups treated with US (9.9 [+ or -] 0.6), US + DCF (11.2 [+ or -] 1.2), or DCF (12.3 [+ or -] 1.2) significantly increased (P < 0.05, 0.01, and 0.001, respectively) the latency time to the heat stimulus compared to the control group (6.5 [+ or -] 0.3) in the Hargreaves test, indicating that these treatments have comparable antinociceptive effects on cutaneous hyperalgesia
. Indomethacin (19.5 [+ or -]0.9), which was used as a standard control drug, increased the latency time to thermal stimulation by 3-fold (Figure 3).
Doctors at the University of Michigan Medical Center, Ann Arbor, note that many patients suffer from opioid-induced hyperalgesia
, or increased sensitivity to pain, which exacerbates existing conditions.
Pain benefits of opioids decreased over time in longer trials, possibly because of opioid tolerance or hyperalgesia
, a condition marked by hypersensitivity to pain.
Magnesium sulfate prevents the development of forced swim induced hyperalgesia
This disparate group of disorders includes pain experienced by both the body and mind: anxiety and depression, complex regional pain syndrome, opioid-induced hyperalgesia
, phantom limb pain, fibromyalgia, and PTSD.
For the observation of mechanical and thermal hyperalgesia
in mice, von Frey filament detection and thermal pain tests were conducted on day 7, 14, 21, 28, 35, and 42 after drug administration.
and Europe discuss the relevant pathophysiologic concepts of genetics, hormones, infections, muscle studies, autoimmunity, small nerve fibers, stress-induced hyperalgesia
, and endogenous pain modulation.
Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia
. Anesthesiology 2004; 101(6): 1400-8.
He had systemic hyperalgesia
in a glove and stocking pattern, slightly diminished perception of rough touch below T12 plane and diminished perception of position and fine touch.
There's also a phenomenon called hyperalgesia
, in which the body of someone who gets used to taking pain medication actually creates a new, stronger pain -- which further fuels the addictive cycle.