hypercholesterolemia


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hy·per·cho·les·ter·ol·e·mi·a

 (hī′pər-kə-lĕs′tər-ə-lē′mē-ə)
n.
1. An excess of cholesterol in the blood.
2. A familial disorder characterized by high serum concentrations of total cholesterol and LDL and normal concentrations of triglycerides.

hy•per•cho•les•ter•ol•e•mi•a

(ˌhaɪ pər kəˌlɛs tər əˈli mi ə)

also hy•per•cho•les•ter•e•mi•a

(-ˌlɛs təˈri-)

n.
the presence of an excessive amount of cholesterol in the blood.
[1890–95; < New Latin]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.hypercholesterolemia - the presence of an abnormal amount of cholesterol in the cells and plasma of the blood; associated with the risk of atherosclerosis
symptom - (medicine) any sensation or change in bodily function that is experienced by a patient and is associated with a particular disease
familial hypercholesterolemia - congenital disorder characterized by high levels of cholesterol and early development of atherosclerosis
Translations

hy·per·cho·les·ter·ol·e·mi·a

References in periodicals archive ?
The Arabic allele: a single base pair substitution activates a 10-base downstream cryptic splice acceptor site in exon 12 of LDLR and severely decreases LDLR expression in two unrelated Arab families with familial hypercholesterolemia.
Methods: Fifty patients with hypercholesterolemia and twenty controls were selected after getting informed consent regarding the investigation of carotid-intima media thickness by B-mode ultrasound.
The molecular analysis of familial hypercholesterolemia (FH), an autosomal dominant disease caused by a multitude of LDL receptor (LDLR) gene mutations, is complicated by mutational heterogeneity of the disease in the majority of population studied to date [10,11].
Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication.
Biopharmaceutical company Regeneron Pharmaceuticals Inc (Nasdaq:REGN) reported on Thursday the receipt of the US Food and Drug Administration (FDA) Breakthrough Therapy designation status for evinacumab for the treatment of hypercholesterolemia in patients with Homozygous Familial Hypercholesterolemia (HoFH).
Keywords: Hypercholesterolemia, atherosclerosis, CD40 ligand cok LDL-kolesterol, trigliserit, 8-OHdG, F1+2 arasinda anlamli korelasyon kurulamamistir (p>0,005).
The other was a rat model, and the animals were fed a high-cholesterol diet, causing diet-induced hypercholesterolemia.
The findings presented at ESC 2016, alongside the six new clinical trials that have begun in the last year, will better define the benefit of Repatha for the many patients who continue to struggle with hypercholesterolemia.
The report provides comprehensive information on the therapeutics under development for Heterozygous familial hypercholesterolemia (heFH), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
9] It was approved by the US-FDA in July 2015 as a first-in-class drug, "for use in addition to diet and maximally tolerated statin therapy in adult patients with heterozygous familial hypercholesterolemia (HeFH) or patients with clinical atherosclerotic cardiovascular disease such as heart attacks or strokes, who require additional lowering of LDL cholesterol.