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n. hipercoagulabilidad, aumento anormal de la coagulabilidad.
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In view of the growing evidence for a role of infection with gram-negative bacteria (3), inflammation, and hypercoagulability in the onset of atherosclerosis, two independent studies evaluated the frequency of a genetic polymorphism within the promotor of the CD14 gene in patients with myocardial infarction (MI) (4,5).
8] If such factors are present, it would be prudent to pursue an evaluation for hypercoagulability.
Septicemia triggers thrombosis through the processes described in Virchow's triad: Stasis, Hypercoagulability and Endothelial Damage.
Factor V mutation-Leiden (FV-Leiden) is a specific point mutation, identified as a G-A substitution in nucleotide 1691 in the factor V gene that leads to Arg506-Gln conversion (2) and is associated with hypercoagulability and increased risk of venous thromboembolism.
3] Hypercoagulability may result from changes in both the coagulation cascade and the fribrinolytic system.
There can be symptoms associated with hypercoagulability particularly due to paraneoplstic syndrome associated with mesothelioma.
The identification of SNPs and other differences within gene coding sequences and the understanding of how these differences influence the function of the gene product will be the basis for defining the genetic causes of a vast majority of medical conditions, from classical genetic diseases to multigenic medical conditions such as cardiovascular disease, arthritis, hypercoagulability, schizophrenia, and almost any other medical condition known.
Hypercoagulability related to hematological or neoplastic abnormalities, venous stasis secondary to extra luminal pressure from tumors or inflammatory processes and vessel injury due to trauma have all been implicated as primary mechanisms in the pathophysiology of IVC thrombosis.