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Excessive insulin in the blood. Also called hyperinsulinism.
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We have been taught that cholesterol found in plaques in the arteries is a result of too much cholesterol in the diet, when in fact the cholesterol is a repair material for vessels damaged by hyperinsulinemia and other conditions.
Hyperinsulinemia and insulin resistance are considered key components in the metabolic cardiovascular syndrome and as independent risk factors for CVD.
This suggests that abdominal obesity and hyperinsulinemia as components of the metabolic syndrome could increase femoral BMD by lowering bone rate.
Whether hyperinsulinemia with euglycemia or intravenous lipid emulsion is superior remains an unresolved question.
Mohit Nagpal, of the Postgraduate Institute of Medical Education and Research, Chandigarh, India, and associates, wrote that "Insulin resistance may be a stage of prediabetes, and the patients may develop hyperinsulinemia or type 2 diabetes in the future.
PCOS is associated with hyperinsulinemia, impaired glucose tolerance, obesity, hyperandrogenism and altered lipid profile.
The patients often develop insulin resistance (IR) or hyperinsulinemia despite manifesting anovulation and signs of hyperandrogenism.
Hyperinsulinemia is a cornerstone of both the metabolic syndrome and PCOS.
3-5) Three metabolic effects of obesity have been found to play a role in systemic health: hyperinsulinemia, hyperglycemia and hyperlipidemia.
Given the patient's obesity (and likely concomitant dyslipidemia, which is commonly encountered in this population) and anovulatory cycles, she is at risk for endometrial pathology because of her chronic exposure to unopposed estrogen, hyperinsulinemia, insulin resistance, and even dysglycemia (commonly encountered in women with pcos).
5] Hyperinsulinemia [6,7] and insulin resistance [6] are commonly associated with PCOS.
Shisheva said that the combined phenotype manifested by the MPlfKO mouse closely recapitulates the cluster of typical features in human prediabetes including systemic glucose intolerance and insulin resistance, hyperinsulinemia and increased visceral obesity without dyslipidemia.