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Excessive response to a stimulus.

hy′per·ir′ri·ta·ble adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌhaɪ pərˌɪr ɪ təˈbɪl ɪ ti)

extreme irritability or sensitivity.
hy`per•ir′ri•ta•ble, adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
Cytotrophic bovine extracts have historically been taken by people with allergic reactions (hives, canker sores, cold blisters), lymph node swelling, blood concerns (anemia, lymphocytosis), demineralization accompanied by hyperirritability, as well as those with lowered resistance to infections and boils.
This disorder is characterized by central nervous system hyperirritability, autonomic nervous system dysfunction, and gastrointestinal disturbances (Stover & Davis, 2015).
(77) demonstrated that MTrP regions exhibit enhanced spontaneous electrical activity at the motor endplate region in the absence of voluntary muscular contraction, suggesting that this may be a valuable objective measure of focal regions of hyperirritability within the muscle.
Asthma is a reversible airway obstruction that is characterized by hyperirritability of the airways, airway inflammation and remodeling of the airways that is associated with constriction of airway smooth muscle, hyper secretion of mucus, edema and thickening of the basement membrane underlying the airway epithelium [1].
As follows, it is speculated that stress of any nature (including psychological stress induced by disfiguring character of the illness and by the torturing pruritus) would be partially responsible for the cutaneous immune reactivity anomalies, the modification of the epidermis barrier function (materialized by susceptibility to cutaneous infections, increased trans epidermal water loss, hyperirritability) and of the cutaneous neuropeptides expression.
Prednisone is another drug used to treat leprosy reactions and that might cause metal disorders, such as: euphoria, mood changes, severe depression with psychotic symptoms, hyperirritability and insomnia.