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n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.

hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pathology) pathol overgrowth and thickening of the outer layer of the skin
hyperkeratotic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌhaɪ pərˌkɛr əˈtoʊ sɪs)

1. proliferation of the cells of the cornea.
2. a thickening of the horny layer of the skin.
hy`per•ker`a•tot′ic (-ˈtɒt ɪk) adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
There is marked papillomatosis with usually mild hyperkeratosis (Figure 2, A).
Mal de Meleda, a hereditary palmoplantar keratoderma, is characterized by symmetrical palmoplantar keratoderma and hyperkeratosis covering the dorsal surface of the hands and feet in a glove/sock form, occurring at birth or within a few years after birth [3].
To the best of our knowledge, there is only a single report in the literature describing dermoscopic features of pachydermodactyly as a cobblestone pattern and whitish scale corresponding to papillomatosis and hyperkeratosis (10).
We propose that pterygium inversum unguis may also be associated with reactive hyperkeratosis and an inflammatory reaction to repeated trauma, as described in the present case.
Mycological investigations were performed in patients with nail changes suspicious for fungal infection such as onychorrhexis, hyperkeratosis, thickening, or crumbling.
Mild hyperkeratosis, acanthosis in the epidermis with elongation of the rete ridges, and dilated vascular structures in the papillary dermis were observed in the histopathologic examination of the lesion (Figure 3).
When area with glabrous skin is grafted with non glabrous skin it results in poor color and texture match, unsightly donor site scar, contractures, hypertrophy, sub graft fibrosis, painful hyperkeratosis buildup in periphery of graft6,7.
COX-2 inhibitors may be helpful as fibroblast exposed to arcoline display on increase in concentration of COX-2 yet the use of COX-2 inhibitors may be restricted to be used in inflammatory phase prior to hyperkeratosis of oral mucosa.
It usually involves the subungueal area with nail hyperkeratosis and dystrophy.
The purpose of this study is to show the significant association of squamous metaplasia (the precursor for cervical cancer), hyperkeratosis, and parakeratosis, and as the Pap smear finding in patients with uterine prolapse, which is sparsely represented in the literature despite the high incidence of the later.