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n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.

hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.


(Pathology) pathol overgrowth and thickening of the outer layer of the skin
hyperkeratotic adj


(ˌhaɪ pərˌkɛr əˈtoʊ sɪs)

1. proliferation of the cells of the cornea.
2. a thickening of the horny layer of the skin.
hy`per•ker`a•tot′ic (-ˈtɒt ɪk) adj.
References in periodicals archive ?
When the biopsy specimen is sent to the dermatopathologist, it's important to provide clinical correlates and a differential diagnosis or the result is likely to be simply descriptive--acanthosis, hyperkeratosis, chronic inflammation--rather than diagnostic.
Hi stological examination of the lesions typically reveals hyperkeratosis with or without parakeratosis, acanthosis, and enlargement of the rete ridges.
These are followed by more specific symptoms of bleeding gums, hyperkeratosis, petechial haemorrhages and delayed wound healing.
Chronic arsenic exposure and oxidative stress: OGG1 expression and arsenic exposure, nail selenium and skin hyperkeratosis in inner Mongolia.
Typical psoriatic nail dystrophy including onycholysis, pitting, and hyperkeratosis observed on current physical examination 3.
Rhiannon was diagnosed with the genetic condition Epidermolytic Hyperkeratosis, a type of ichthyosis, at just 12 hours old.
Microscopic evaluation, to confirm the diagnosis, shows varying degrees of hyperkeratosis, acanthosis, and parakeratosis accompanied by a diffuse infiltration of large vacuolated pale staining cells, often with a bluish cytoplasm predominantly found in the lower layers of the epidermis; they can also be present in the epithelium of the underlying adnexal structures.
Naso-digital hyperkeratosis - this disease occurs in older dogs where there is no known cause but it can also be a component of other disorders, such as a food allergy, an immune problem or a bacterial infection.
Salicylic acid is used to treat hyperkeratosis of the follicular epithelium in acne vulgaris skin lesions.
According to the World Health Organization, some of the known health hazards of chronic arsenic ingestion through drinking water include cancer of the skin, lungs, bladder and kidney, as well as other skin changes such as pigmentation and thickening, also known as hyperkeratosis.
For the combination group compared to the vemurafenib group, there was a lower incidence of rash, 22% (n=76) vs 43% (n=149); photosensitivity reaction, 4% (n=13) vs 22% (n=78); hand-foot syndrome, 4% (n=14) vs 25% (n=87); skin papillomas, 2% (n=6) vs 23% (n=80); squamous-cell carcinomas and keratoacanthomas, 1% (n=5) vs 18% (n=63); and hyperkeratosis, 4% (n=15) vs 25% (n=86).
The clinical features of onychomycosis (Table 1) include nail bed hyperkeratosis with subsequent separation of the nail plate from the nail bed (onycholysis), the presence of subungual debris, and nail plate dyschromia.