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n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.

hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.


(Pathology) pathol overgrowth and thickening of the outer layer of the skin
hyperkeratotic adj


(ˌhaɪ pərˌkɛr əˈtoʊ sɪs)

1. proliferation of the cells of the cornea.
2. a thickening of the horny layer of the skin.
hy`per•ker`a•tot′ic (-ˈtɒt ɪk) adj.
References in periodicals archive ?
According to published literature, hyperkeratosis alone has not been attributed to the development of cervical dysplasia, yet increased keratinization is often noted as a characteristic of dysplastic lesions.
7 The associated nail dystrophy consists of alternating longitudinal red and white streaks, subungual hyperkeratosis, splintering, fragility, and marginal V-shaped nicking.
Moderate to severe tarsal hyperkeratosis was present in 13 birds (48%).
Hyperkeratosis and acanthosis were more prominent in lichen amyloidosis compared to macular amyloidosis.
Papillon-Lefevre syndrome (PLS) is a rare genodermatosis of autosomal recessive inheritance manifesting as palmar and plantar hyperkeratosis with periodontitis.
Clinical findings include red-to-salmon-colored follicular hyperkeratosis that forms papules or plaques with scales.
When area with glabrous skin is grafted with non glabrous skin it results in poor color and texture match, unsightly donor site scar, contractures, hypertrophy, sub graft fibrosis, painful hyperkeratosis buildup in periphery of graft6,7.
COX-2 inhibitors may be helpful as fibroblast exposed to arcoline display on increase in concentration of COX-2 yet the use of COX-2 inhibitors may be restricted to be used in inflammatory phase prior to hyperkeratosis of oral mucosa.
The cytological findings such as squamous metaplasia, hyperkeratosis, parakeratosis, and reactive cellular changes were noted specifically in patients with or without uterine prolapse.