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Related to hyperkeratotic: hyperkeratosis, keratoacanthoma, acanthosis, exophytic


n. pl. hy·per·ker·a·to·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.

hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pathology) pathol overgrowth and thickening of the outer layer of the skin
hyperkeratotic adj
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌhaɪ pərˌkɛr əˈtoʊ sɪs)

1. proliferation of the cells of the cornea.
2. a thickening of the horny layer of the skin.
hy`per•ker`a•tot′ic (-ˈtɒt ɪk) adj.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
ILVEN is a hamartoma that usually is congenital or presents in early childhood; presents with linear or whorled, hyperkeratotic papules and plaque in similar linear "line of Blaschko" patterns; and represents cutaneous mosaicism.
A dermatological examination revealed bilateral palmoplantar pointed pits, maceration, and foul odor between the toes on slightly erythematous yellowish hyperkeratotic areas extending to the dorsal aspect of the hands and feet (Figure 2).
The patient had 3 confluent, but distinct, lesions on her forehead: an erythematous crateriform nodule with overlying hyperkeratotic scale (FIGURE, Lesion A); a nodular hyperpigmented plaque with irregular color and borders (Lesion B); and a pearly well-vascularized erythematous nodule with surrounding hemorrhagic crust (Lesion C).
Also, yellowish-brown-colored hyperkeratotic plagues on the medial parts of both knees, and lateral and medial malleols (Figure 1-3), were observed.
Multiple flat and hyperkeratotic lesions on the left palm, with a thrombosed blood vessel on the center of lesions.
Elevated Plasma Tyrosine Levels, Ocular Symptoms, Developmental Delay and Hyperkeratotic Plaques: Inadequate restriction of tyrosine and phenylalanine intake can lead to elevations in plasma tyrosine, which at levels above 500 micromol/L can result in symptoms, intellectual disability and developmental delay or painful hyperkeratotic plaques on the soles and palms; do not adjust the dosage of NITYR in order to lower the plasma tyrosine concentration.
The striking clinical finding of hyperkeratotic coat of armour encasing the baby prompted us to the diagnosis of Harlequin ichthyosis.3
Cutaneous horn (Cornu cutaneum) is a relatively uncommon lesion consisting of a projectile, conical, dense, hyperkeratotic nodule, which resembles the horn of an animal.
[1] Clinically, it is characterized by sharply demarcated margins with hyperkeratotic sim so its clinical presentation is unique.
They have been described in chronic sun-damaged skin with precancerous lesions (5-7), in the periphery of hyperkeratotic Bowen's disease (8) and basal cell carcinoma (9), in poromas (10), in psoriasis (11), and in cutaneous leishmaniasis (12, 13).
Examination revealed findings of extensive raised, erythematous, hyperkeratotic, macerated lesions throughout the vulva.
The authors suggested that HK may be a "hyperkeratotic" variant of idiopathic guttate hypomelanosis [2].