ILVEN is a hamartoma that usually is congenital or presents in early childhood; presents with linear or whorled, hyperkeratotic
papules and plaque in similar linear "line of Blaschko" patterns; and represents cutaneous mosaicism.
A dermatological examination revealed bilateral palmoplantar pointed pits, maceration, and foul odor between the toes on slightly erythematous yellowish hyperkeratotic
areas extending to the dorsal aspect of the hands and feet (Figure 2).
The patient had 3 confluent, but distinct, lesions on her forehead: an erythematous crateriform nodule with overlying hyperkeratotic
scale (FIGURE, Lesion A); a nodular hyperpigmented plaque with irregular color and borders (Lesion B); and a pearly well-vascularized erythematous nodule with surrounding hemorrhagic crust (Lesion C).
Also, yellowish-brown-colored hyperkeratotic
plagues on the medial parts of both knees, and lateral and medial malleols (Figure 1-3), were observed.
Multiple flat and hyperkeratotic
lesions on the left palm, with a thrombosed blood vessel on the center of lesions.
Elevated Plasma Tyrosine Levels, Ocular Symptoms, Developmental Delay and Hyperkeratotic
Plaques: Inadequate restriction of tyrosine and phenylalanine intake can lead to elevations in plasma tyrosine, which at levels above 500 micromol/L can result in symptoms, intellectual disability and developmental delay or painful hyperkeratotic
plaques on the soles and palms; do not adjust the dosage of NITYR in order to lower the plasma tyrosine concentration.
The striking clinical finding of hyperkeratotic
coat of armour encasing the baby prompted us to the diagnosis of Harlequin ichthyosis.3
Cutaneous horn (Cornu cutaneum) is a relatively uncommon lesion consisting of a projectile, conical, dense, hyperkeratotic
nodule, which resembles the horn of an animal.
 Clinically, it is characterized by sharply demarcated margins with hyperkeratotic
sim so its clinical presentation is unique.
They have been described in chronic sun-damaged skin with precancerous lesions (5-7), in the periphery of hyperkeratotic
Bowen's disease (8) and basal cell carcinoma (9), in poromas (10), in psoriasis (11), and in cutaneous leishmaniasis (12, 13).
Examination revealed findings of extensive raised, erythematous, hyperkeratotic
, macerated lesions throughout the vulva.
The authors suggested that HK may be a "hyperkeratotic
" variant of idiopathic guttate hypomelanosis .