Objective: After a four-year program of research and development MONTELOEDER has identified highly active components in well-known and safe herbal extracts (Hibiscus sabdariffa and ; Lemon verbena) that preclinical results shows to modulate triglyceride accumulation, oxidative stress and inflammation in insulin-resistant adipocytes and their capacity to decrease body weight, serum cholesterol and triglycerides levels and hepatic steatosis signs in a hyperlipidemic
mouse model subjected to high-fat diets.
The Phase 3 program includes 16 trials to evaluate Repatha administered every two weeks and monthly in multiple patient populations, including in combination with statins in patients with hyperlipidemia (LAPLACE-2 and YUKAWA-2); in patients with hyperlipidemia who cannot tolerate statins (GAUSS-2 and GAUSS-3); as a stand-alone treatment in patients with hyperlipidemia (MENDEL-2); in patients whose elevated cholesterol is caused by genetic disorders called heterozygous (RUTHERFORD-2 and TAUSSIG) and homozygous (TESLA and TAUSSIG) familial hypercholesterolemia; the effects of Repatha on lipoprotein metabolism (FLOREY); and the administration of Repatha in statin-treated hyperlipidemic
patients (THOMAS-1 and THOMAS-2).
In a randomized, placebo-controlled study, half of a group of 80 hyperlipidemic
type II diabetics were given a 500 mg capsule of sage leaf extract three times a day, while other participants were given a placebo.
Vitamins and herbal antioxidants reduce the risk of cardiovascular diseases probably through decreasing free radicals; they improve endothelial function in hyperlipidemic
Medico-legal questions to be addressed are whether the company had prior knowledge of the risk and failed to warn and were the patients actually harmed by Lipitor and not their diabetes, given that diabetes is a very common disease and may be linked more to genetics and/or an underlying metabolic syndrome in those who are hyperlipidemic
, hypertensive, or obese--the very same patients likely to be on a statin?
In the current study, jatrorrhizine isolated from RC was subjected to investigate its toxicity and antihyperlipidemic activity on hyperlipidemic
Syrian golden hamsters induced by high-fat and high-cholesterol diet (HFHC).
A flaxseed supplement consisting of three slices of flaxseed-containing bread and 15 g of ground flaxseed was studied in 15 hyperlipidemic
patients, and total and low-density lipoprotein cholesterol levels were reduced significantly, 18 mg/dL and 19 mg/dL respectively.
There was an average age of 67 years, 90% of patients were current or ex-smokers, 75% were hypertensive, 32% diabetic and 79% hyperlipidemic
Analytical performance and clinical utility of a direct LDL-cholesterol assay in a hyperlipidemic
Triglyceride levels of 150 mg/dL or higher and cholesterol levels of 250 mg/dL or higher were considered as hyperlipidemic
The survey did not assess the performance of these assays in hyperlipidemic
individuals or in those with conditions known to affect lipoprotein composition.
During this study period, the colonoscopy SCI group was hypertensive (75%), hyperlipidemic
(79%), had a higher BMI (p = 0.