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(ˌhaɪ pərˌlɪp əˌproʊ tiˈni mi ə, -ˌproʊ ti ə-, -ˌlaɪ pə-)

any of various disorders of lipoprotein metabolism, usu. characterized by abnormally high levels of cholesterol and certain lipoproteins in the blood.
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Noun1.hyperlipoproteinemia - any of various disorders of lipoprotein and cholesterol metabolism that result in high levels of lipoprotein and cholesterol in the circulating blood
metabolic disorder - a disorder or defect of metabolism
hyperbetalipoproteinemia - a genetic disorder characterized by high levels of beta-lipoproteins and cholesterol; can lead to atherosclerosis at an early age
References in periodicals archive ?
3] To date, xanthoma of the bone has not been found in any patient with familial type III hyperlipoproteinemia.
These particles have either (1) a much higher proportion of cholesterol as found in individuals with type III hyperlipoproteinemia (more than 30% of mass as cholesterol), or (2) a much lower proportion of cholesterol, as in the case of nonfasting samples where chylomicrons are present (less than 10% of mass as cholesterol).
E2/E2 homozygosity occurs in approximately 1 % of the population and contributes to expression of type III hyperlipoproteinemia, characterized by roughly equimolar elevations of plasma cholesterol and triglycerides and by early cardiovascular disease (9).
To obtain the VLDLR fraction from the serum of a patient with type III hyperlipoproteinemia, we conducted ultracentrifugation and gel filtration.
Estimation with the Friedewald equation is widely used (6), although the calculated values can be inaccurate for plasma triglyceride (TG) concentrations >4000 mg/L or in the presence of chylomicrons or type III hyperlipoproteinemia.
ZOCOR is indicated to reduce elevated LDL cholesterol and triglyceride levels in patients with Type IIb hyperlipoproteinemia (where hypercholesterolemia is the major abnormality).
Type III hyperlipoproteinemia (dysbetalipoproteinaemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism.
Familial type I hyperlipoproteinemia caused by apolipoprotein C-II deficiency.
Homozygosity for E2 predisposes to the development of type III hyperlipoproteinemia attributable to delayed metabolic clearance of apoE-containing lipoproteins.
Gel isoelectric focusing method for specific diagnosis of familial hyperlipoproteinemia type 3.
Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158->Cys) homorygotes is associated with hyperinsulinemia.