hypermutable


Also found in: Medical.

hypermutable

(ˌhaɪpəˈmjuːtəbəl)
adj
(Medicine) med characterized by a rapid occurrence of mutation
References in periodicals archive ?
Long-term dissemination of CTX-M-5-producing hypermutable Salmonella enterica serovar Typhimurium sequence type 328 strains in Russia, Belarus, and Kazakhstan.
Increasing prevalence and dissemination of invasive nontyphoidal Salmonella serotype Typhimurium with multidrug resistance in hospitalized patients from southern Brazil
Amiche, "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain," European Journal of Biochemistry, vol.
Discovery of Novel Caeridins from the Skin Secretion of the Australian White's Tree Frog, Litoria caerulea
Microsatellite instability (MSI) is a hypermutable phenotype with a predisposition to genetic mutations due to a deficient mismatch repair (dMMR) system.
A Contemporary Review of the Treatment Landscape and the Role of Predictive and Prognostic Biomarkers in Pancreatic Adenocarcinoma
This results in microsatellite instability and can lead to a hypermutable phenotype [96].
Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine
This finding indicates that the emergence of levofloxacin-resistant isolates likely occurred through spontaneous mutation of hypermutable clones under selective pressure (8,14), and these clones then disseminated locally in each region.
Levofloxacin-resistant Haemophilus influenzae, Taiwan, 2004-2010
Alterations in the MMR genes usually result in the accumulation of replication errors, resulting in a hypermutable phenotype known as microsatellite instability (MSI), which occurs in a high percentage of Lynch syndrome tumors [9].
Report of a novel mutation in MLH1 gene in a Hispanic family from Puerto Rico fulfilling classic Amsterdam criteria for Lynch syndrome
"To the contrary, disease-causing genes tend to be hypermutable."
Life Emerged from Cell Membrane Bioenergetics?
Hypermutable strains of Pseudomonas aeruginosa with defects in the methyl directed mismatch repair (MMR) system are also being frequently isolated from the lungs of cystic fibrosis (CF) patients6,8.
IN VITRO EFFICACY OF PIPERACILLIN/SULBACTAM, PIPERACILLIN/TAZOBACTAM AND CEFOPERAZONE/SULBACTAM AGAINST CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA - A COMPARATIVE STUDY
Familial colorectal cancer in Askenazim due to a hypermutable tract in APC.
A review on cancer genetic
[16] Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.
Fsdf [alg.sub.s] genes: [H.sub.2][O.sub.2] map their viability and validity in Pseudomonas aeruginosa
Of note is that numerous mutations have been described in the BHD gene, most of which have been located within a hypermutable 8 cytosine tract and result in a truncated form of folliculin.
Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities
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