hypermutable


Also found in: Medical.

hypermutable

(ˌhaɪpəˈmjuːtəbəl)
adj
(Medicine) med characterized by a rapid occurrence of mutation
References in periodicals archive ?
This finding indicates that the emergence of levofloxacin-resistant isolates likely occurred through spontaneous mutation of hypermutable clones under selective pressure (8,14), and these clones then disseminated locally in each region.
To the contrary, disease-causing genes tend to be hypermutable.
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.
Hypermutable strains of Pseudomonas aeruginosa with defects in the methyl directed mismatch repair (MMR) system are also being frequently isolated from the lungs of cystic fibrosis (CF) patients6,8.
16] Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.
Familial colorectal cancer in Askenazim due to a hypermutable tract in APC.
Of note is that numerous mutations have been described in the BHD gene, most of which have been located within a hypermutable 8 cytosine tract and result in a truncated form of folliculin.
Exton, PA) has patented dominant-negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms.
Although one of the hypermutable populations exhibited an unusually high level of variation for fitness, the other hypermutable population did not.
Resolution of nearly identical genotypes might also be accomplished by using additional VNTRs (8) or hypermutable loci (9).