hypermutable

Also found in: Medical.

hypermutable

(ˌhaɪpəˈmjuːtəbəl)

adj

(Medicine) med characterized by a rapid occurrence of mutation

References in periodicals archive ?

This finding indicates that the emergence of levofloxacin-resistant isolates likely occurred through spontaneous mutation of hypermutable clones under selective pressure (8,14), and these clones then disseminated locally in each region.

Levofloxacin-resistant Haemophilus influenzae, Taiwan, 2004-2010

To the contrary, disease-causing genes tend to be hypermutable.

Life Emerged from Cell Membrane Bioenergetics?

Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.

Biopeliculas multi-especie: asociarse para sobrevivir

Hypermutable strains of Pseudomonas aeruginosa with defects in the methyl directed mismatch repair (MMR) system are also being frequently isolated from the lungs of cystic fibrosis (CF) patients6,8.

IN VITRO EFFICACY OF PIPERACILLIN/SULBACTAM, PIPERACILLIN/TAZOBACTAM AND CEFOPERAZONE/SULBACTAM AGAINST CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA - A COMPARATIVE STUDY

16] Ciofu O, Riis B, Pressler T, Poulsen HE, Hoiby N Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation.

Fsdf [alg.sub.s] genes: [H.sub.2][O.sub.2] map their viability and validity in Pseudomonas aeruginosa

Familial colorectal cancer in Askenazim due to a hypermutable tract in APC.

A review on cancer genetic

Of note is that numerous mutations have been described in the BHD gene, most of which have been located within a hypermutable 8 cytosine tract and result in a truncated form of folliculin.

Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities

Exton, PA) has patented dominant-negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms.

Morphotek obtains United States patent

Although one of the hypermutable populations exhibited an unusually high level of variation for fitness, the other hypermutable population did not.

Mechanisms maintaining genetic variability within populations

Resolution of nearly identical genotypes might also be accomplished by using additional VNTRs (8) or hypermutable loci (9).